Rotavirus vaccines: current prospects and future challenges

Safety and Immunogenicity of Sequential Rotavirus Vaccine Schedules

“…4,22 During routine rotavirus immunization of young children it is likely that mixed schedules of the 2 vaccines are administered to infants. In fact, a recently published study 6 …”

“…A subject was considered to have a seropositive result if the IgA antibody concentration determined using either virus was ≥20 U/mL. 16 Neutralizing antibody was determined against several rotavirus strains representing the common G and P types: Wa(G1P [8]), DS-1(G2P [4]), P(G3P [8]), ST3(G4P [6 ]), VA70(G4P [8]), and CCHMC-G9P6(G9P [6]) by using a method described previously. 17 A subject was considered to have a seropositive result for neutralizing antibody if the titer determined against any virus was ≥10.…”

“…These vaccines use different principles to achieve broad-range immunity against diverse strains. 4,5 RV5 is a live, oral vaccine that contains a combination of 5 human/ bovine reassortant rotaviruses. 6,7 Three doses of the vaccine are recommended.…”

Hospitalization due to norovirus and genotypes of rotavirus in pediatric patients, state of Espírito Santo

“…Many infectious agents (bacteria, parasites and viruses) can be associated, but viruses are mainly responsible for endemic and epidemic gastroenteritis, mostly represented by group A rotaviruses (RV) and noroviruses (NoV). Although with low mortality in developed countries, gastroenteritis is one of the most common illnesses requiring hospitalization in an estimated one out of five cases, making this a serious public-health matter (Glass et al 2006).…”

“…RV, a member of Reoviridae family, is recognized as the most significant cause of diarrheic illness attacking children up to the age of three, worldwide (Glass et al 2006). RVs are classified into seven groups (A-G) based on the VP6 intermediary capsid protein, of which three (A-C) are human pathogens; group A is responsible for 95% of infections (Kapikian et al 2001).…”