Rothia dentocariosa, endocarditis and mycotic aneurysms: case report and review of the literature

Abstract

Rothia dentocariosa is a rare cause of endocarditis. It occurs most frequently in patients with prior heart conditions. Although the clinical course is typically subacute, it has a high rate of complications. In particular, the reported incidence of mycotic aneurysms is as high as 25%. Penicillin is the treatment of choice, but additional complications may necessitate prompt surgical intervention. As far as we know, this paper reports the first case of repeated subarachnoid hemorrhages due to R. dentocariosa endocarditis.

Rothia dentocariosa Endocarditis: An Especially Rare Case in a Previously Healthy Man

“…Boudewijns and colleagues 6 reviewed all cases reported in the literature up to 2002, totaling 20 patients. Since then, only 3 other cases of R. dentocariosa endocarditis have been reported.…”

“…[1][2][3][4][5] It is noted that only a few cases of R. dentocariosa endocarditis have been reported to date, almost exclusively in patients with an underlying heart condition as the predisposing risk factor. 6 We present a case of a previously healthy patient with endocarditis caused by this rare organism.…”

Rothia genus endophthalmitis following penetrating injury in a child

“…1 Rothia dentocariosa has been linked with human disease such as endocarditis, mycotic aneurysms, osteomyelitis, septicaemia, pneumonia, and peritonitis. [2][3][4][5][6][7] Endophthalmitis has been reported in an adult following multiple surgeries. The visual outcome was poor.…”

Antimicrobial peptides and the interplay between microbes and host : towards preventing porcine infections with Streptococcus suis

“…These and other common mechanisms of resistance to AMPs are highlighted in Figure 6. [75] costs, rapid growth on inexpensive substrates, controllable laboratory conditions, and the generally well-characterized genetic backgrounds and availability of a wide range of vectors and host strains [93]. The use of fusion proteins is common in the production of small, labile AMPs to provide stabilization, shield the AMP from intracellular proteolytic degradation, increase expression and facilitate downstream purification processes, but more importantly to mask the intrinsic toxicity of these peptides to the expression host [91,94,95].…”

“…Rothia spp. are not considered to be obligate pathogens, but R. dentocariosa has been associated with dental and periodontal ailments, and rare cases of systemic infection such as peritonitis [92] or endocarditis [93,94]. Rothia mucilaginosa is often present in high abundance in the lung of cystic fibrosis patients [95] and usually treated as part of the normal oral microbiota, but its significance in pulmonary disease may be underestimated due to possible misidentification of the infecting microbe [96].…”