Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance

Wonkam, Argan Kelly Nkwenti; Ngansop, Cyrille Armel Njanpa; Wouamba, Steven Collins Njonte; Jouda, Jean-Bosco; Happi, Gervais Mouthé; Boyom, Fabrice Fekam; Sewald, Norbert; Lenta, Bruno Ndjakou

doi:10.1016/j.bse.2020.104137

Cited by 5 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The double bond detected on the sphingosine moiety is found to be in the ( E )-configuration. This assumption is deduced from the chemical shift of the allylic carbons; when their δ C is ranging from 27–28 ppm, the double bond is ( Z )-configuration, while when δ C is ranging from 31–34 ppm, the double bond is ( E )-configuration [ 11 , 12 , 14 , 17 , 18 , 19 ]. The stereochemistry 2 S , 3 S , 4 R, and 2′ R of compound 1 was proposed based on the comparison of the 13 C-NMR chemical shifts of C-2, C-3, C-4, and C-2′ with those of aralia cerebroside, plakosides C and D, and gynuramide II [ 13 , 14 , 20 , 21 ], which is in accordance with the natural occurring phytoceramide as well as cerebroside [ 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae)

et al. 2023

View full text Add to dashboard Cite

Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1) together with five known compounds (2–6) were isolated from the root barks of Antrocaryon klaineanum using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds 1–4 are reported for the first time from A. klaineanum. The methanol crude extract (AK-MeOH), the n-hexane fraction (AK-Hex), the dichloromethane fraction (AK-DCM), the ethyl acetate fraction (AK-EtOAc), and compounds 1–6 were all evaluated for their antiparasitic effects against Plasmodium falciparum strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of Leishmania donovani (MHOM/SD/62/1S). The AK-Hex, AK-EtOAc, AK-MeOH, and compound 2 were strongly active against Dd2 strain with IC50 ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, AK-MeOH was the most active—more than the reference drugs used—with an IC50 of 2.78 ± 0.06 µg/mL. The AK-EtOAc as well as all the tested compounds showed strong antileishmanial activities with IC50 ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL.

show abstract