Rotor Design and Optimization of Synchronous Reluctance Machine

Bárta, Jan; Ondrůšek, Čestmír

doi:10.17973/mmsj.2015_03_201504

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…Portola Pharmaceuticals have reported tetrahydroisoquinolines that increased both LDL uptake into liver cells and LDLR cell surface populations. 29 Similarly, Park and co-workers reported compounds that had the same types of activities and reduced LDL in wild-type mice but not the corresponding in a PCSK9 knock out murine model. 30,31 The Park compounds have fragments that structurally resemble the plasticizer bisphenol A (BPA).…”

Section: Introductionmentioning

confidence: 98%

Small Molecule Inhibitors of the PCSK9·LDLR Interaction

et al. 2018

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The protein-protein interaction between proprotein convertase subtilisin/kexin type 9 (PCSK9) and low-density lipoprotein receptor (LDLR) is a relatively new, and extremely important, validated therapeutic target for treatment and prevention of heart disease. Experts in the area agree that the first small molecules to disrupt PCSK9·LDLR would represent a milestone in this field, yet few credible leads have been reported. This paper describes how side-chain orientations in preferred conformations of carefully designed chemotypes were compared with LDLR side chains at the PCSK9·LDLR interface to find molecules that would mimic interface regions of LDLR. This approach is an example of the procedure called EKO (Exploring Key Orientations). The guiding hypothesis on which EKO is based is that good matches indicate the chemotypes bearing the same side chains as the protein at the sites of overlay have the potential to disrupt the parent protein-protein interaction. In the event, the EKO procedure and one round of combinatorial fragment-based virtual docking led to the discovery of seven compounds that bound PCSK9 (SPR and ELISA) and had a favorable outcome in a cellular assay (hepatocyte uptake of fluorescently labeled low-density lipoprotein particles) and increased the expression LDLR on hepatocytes in culture. Three promising hit compounds in this series had dissociation constants for PCSK9 binding in the 20-40 μM range, and one of these was modified with a photoaffinity label and shown to form a covalent conjugate with PCSK9 on photolysis.

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Section: Introductionmentioning

confidence: 98%

Small Molecule Inhibitors of the PCSK9·LDLR Interaction

et al. 2018

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“…For example, in the design of electrical machines, flux barriers inside the rotor or stator design spaces can be added and optimized for performance improvement. If the geometry optimization is utilized for the flux barriers, it increases the optimization variables and is not flexible to get the optimal shape [61][62][63][64]. Nevertheless, the TO approach can lead to more efficient and lightweight designs, but it is generally more computationally intensive and requires specialized software [65][66][67].…”

Section: Optimization Of Am Electrical Machinesmentioning

confidence: 99%

Recent Trends in Additive Manufacturing and Topology Optimization of Reluctance Machines

2023

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Additive manufacturing (AM) or 3D printing has opened up new opportunities for researchers in the field of electrical machines, as it allows for more flexibility in design and faster prototyping, which can lead to more efficient and cost-effective production. An overview of the primary AM techniques utilized for designing electrical machines is presented in this paper. AM enables the creation of complex and intricate designs that are difficult or impossible to achieve using traditional methods. Topology Optimization (TO) can be used to optimize the design of parts for various purposes such as weight, thermal, material usage and structural performance. This paper primarily concentrates on the most recent studies of the AM and TO of the reluctance machines. The integration of AM with TO can enhance the design and fabrication process of magnetic components in electrical machines by overcoming current manufacturing limitations and enabling the exploration of new design possibilities. The technology of AM and TO both have limitations and challenges which are discussed in this paper. Overall, the paper offers a valuable resource for researchers and practitioners working in the field of AM and TO of electrical machines.

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“…Another type of optimization, topology optimization (TO), allows the topology of the structure to evolve to a new topology in an iterative way. For example, flux barriers inside the rotor or the stator design spaces could be added and optimized for performance improvement [187], [188], [189]. These barriers increase the number of optimizable parameters if geometry optimization is used, which increases computation time and complexity [190].…”

Section: Topology Optimization Of Srmsmentioning

confidence: 99%

Geometry and Topology Optimization of Switched Reluctance Machines: A Review

Abdalmagid

Sayed²,

Bakr

et al. 2022

IEEE Access

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Switched reluctance machines (SRMs) have recently attracted more interest in many applications due to the volatile prices of rare-earth permanent magnets (PMs) used in permanent magnet synchronous machines (PMSMs). They also have rugged construction and can operate at high speeds and high temperatures. However, acoustic noise and high torque ripples, in addition to the relatively low torque density, present significant challenges. Geometry and topology optimization are applied to overcome these challenges and enable SRMs to compete with PMSMs. Key geometric design parameters are optimized to minimize various objective functions within geometry optimization. On the other hand, the material distribution in a particular design space within the machine domain may be optimized using topology optimization. We discuss how these techniques are applied to optimize the geometries and topologies of SRMs to enhance machine performance. As optimizing the machine geometry and material distribution at the design phase is of substantial significance, this work offers a comprehensive literature review on the current state of the art and the possible trends in the optimization techniques of SRMs. The paper also reviews different configurations of SRMs and stochastic and deterministic optimization techniques utilized in optimizing different configurations of the machine.

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Rotor Design and Optimization of Synchronous Reluctance Machine

Cited by 13 publications

References 7 publications

Small Molecule Inhibitors of the PCSK9·LDLR Interaction

Small Molecule Inhibitors of the PCSK9·LDLR Interaction

Recent Trends in Additive Manufacturing and Topology Optimization of Reluctance Machines

Geometry and Topology Optimization of Switched Reluctance Machines: A Review

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