Round window membrane and labyrinthine pathological changes: an overview

Cüreoğlu, Sebahattin; Schachern, Patricia A.; Rinaldo, Alessandra; Tsuprun, Vladimir; Ferlito, Alfio; Paparella, Michael M.

doi:10.1080/00016480410022534

Cited by 54 publications

(43 citation statements)

References 56 publications

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“…Although the round window membrane in humans is much thicker than that in a guinea pig, a water-tight seal is achieved similarly by a single layer of cells: the outer epithelium [Goycoolea and Lundman, 1997;Carpenter et al, 1989;Cureoglu et al, 2005]. The membrane morphology changes due to otitis media [Sahni et al, 1987] are similar to the observations in guinea pig OME models [Cureoglu et al, 2005].…”

Section: Change In Cochlear Response In Ome Earssupporting

confidence: 70%

“…The membrane morphology changes due to otitis media [Sahni et al, 1987] are similar to the observations in guinea pig OME models [Cureoglu et al, 2005]. In other words, the guinea pig OME model with a much thinner round window membrane is presumably a reasonable model for the influence of middle ear pathology affecting the human round window.…”

Section: Change In Cochlear Response In Ome Earssupporting

confidence: 66%

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Change in Cochlear Response in an Animal Model of Otitis Media with Effusion

Dai

Gan²

2009

Audiol Neurotol

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Our previous studies confirm that middle ear mobility is reduced in the presence of otitis media with effusion (OME). Variations in middle ear function may result in changes in cochlear response in OME ears. With the long-term goal of evaluating cochlear function in OME ears, the aim of this study was to measure the displacement of the basilar membrane (BM) in guinea pig ears with OME. Vibrations of the BM at the apex and basal turn were measured in an in vitro preparation extracted 3 and 14 days after injection of lipopolysaccharide in the middle ear of guinea pigs. The results show that the displacement sensitivity of the BM at the apex and the basal turn to sound pressure in the ear canal was reduced up to 25 dB at their characteristic frequencies, respectively. Cochlear gain with respect to umbo movement was also changed in ears with OME in both groups. This study provides data for analysis of the change of BM vibration in a guinea pig OME model.

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Section: Change In Cochlear Response In Ome Earssupporting

confidence: 70%

Section: Change In Cochlear Response In Ome Earssupporting

confidence: 66%

Change in Cochlear Response in an Animal Model of Otitis Media with Effusion

Dai

Gan²

2009

Audiol Neurotol

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“…However, the effectiveness of some pharmacological agents may be compromised by their non-uniform distribution within the cochlea, with relatively high concentrations detected in the basal turn near the round window, and little evidence of the drug reaching the apical turn [77,78]. The permeability of the human round window may also differ from experimental animals, as well as between individuals due to cochlear pathologies, suggesting that the effectiveness of this route may be variable [79].…”

Section: Delivery Techniques For Neurotrophin Administration In the Cmentioning

confidence: 99%

Neurotrophic Factors and Neural Prostheses: Potential Clinical Applications Based Upon Findings in the Auditory System

Pettingill

Richardson

Wise

et al. 2007

IEEE Trans. Biomed. Eng.

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Spiral ganglion neurons (SGNs) are the target cells of the cochlear implant, a neural prosthesis designed to provide important auditory cues to severely or profoundly deaf patients. The ongoing degeneration of SGNs that occurs following a sensorineural hearing loss is therefore considered a limiting factor in cochlear implant efficacy. We review neurobiological techniques aimed at preventing SGN degeneration using exogenous delivery of neurotrophic factors. Application of these proteins prevents SGN degeneration and can enhance neurite outgrowth. Furthermore, chronic electrical stimulation of SGNs increases neurotrophic factor-induced survival and is correlated with functional benefits. The application of neurotrophic factors has the potential to enhance the benefits that patients can derive from cochlear implants; moreover, these techniques may be relevant for use with neural prostheses in other neurological conditions.

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“…Overwhelming evidence from human temporal bone studies and experimental studies in animals suggests that toxins or inflammatory mediators from otitis media enter and affect the labyrinth by crossing the round window membrane [1] (review). In serous labyrinthitis, one of the most common complications occurring during otitis media, invasion by bacterial or viral toxins inflames the vestibular apparatus and the cochlea.…”

Section: Introductionmentioning

confidence: 99%

Childhood otitis media is associated with dizziness in adulthood: the HUNT cohort study

Aarhus

Tambs

Hoffman

et al. 2015

Eur Arch Otorhinolaryngol

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Objective: To examine the association between otitis media in childhood and dizziness in adulthood.Design: Longitudinal, population-based cohort study of 21,962 adults (aged 20-59 years, mean 40) who completed a health questionnaire in the Nord-Trøndelag Hearing Loss Study. At 7, 10 and 13 years of age, the same individuals underwent screening audiometry in a longitudinal school hearing investigation. Children found with hearing loss underwent an ear, nose and throat specialist examination.Results: Adults diagnosed with childhood chronic suppurative otitis media (n=102) and childhood hearing loss after recurrent acute otitis media (n=590) were significantly more likely to have increased risk of reported dizziness when compared to adults with normal hearing as children at the school investigation and also a negative history of recurrent otitis media (n=21,270), p<0.05. After adjusting for adult age, sex and socio-economic status, the odds ratios were 2.1 (95% confidence interval [CI]: 1.4-3.3) and 1.3 (95% CI: 1.0-1.5), respectively. Conclusion:This longitudinal cohort study suggests that childhood chronic suppurative otitis media and childhood hearing loss after recurrent acute otitis media are associated with increased risk of dizziness in adulthood. This might reflect a permanent effect of inflammatory mediators or toxins on the vestibular system. The new finding stresses the importance of treatment and prevention of these otitis media conditions.

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Round window membrane and labyrinthine pathological changes: an overview

Cited by 54 publications

References 56 publications

Change in Cochlear Response in an Animal Model of Otitis Media with Effusion

Change in Cochlear Response in an Animal Model of Otitis Media with Effusion

Neurotrophic Factors and Neural Prostheses: Potential Clinical Applications Based Upon Findings in the Auditory System

Childhood otitis media is associated with dizziness in adulthood: the HUNT cohort study

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