In this paper, we focus on the design of different node architectures suitable for Few-Mode Multi-Core Fibers (FM-MCFs) based networks. Both dimensions, core and mode, open different possible ways to group spatial channels depending on the physical impairments of the Space-Division Multiplexed (SDM) optical fibers. Moreover, the channel switching across a group of cores/modes at once and the end-to-end routing are not only mandatory aspects for certain spatial channels, but also recommendable in order to reduce the node complexity/cost. Thus, we propose various SDM-capable node architectures based on versatile and homogeneous spatial group configurations. Then, a unified physical-layer-aware Quality of Transmission (QoT) estimator is formulated to not only evaluate these node architectures in a simulation tool, but also validate them in a real experimental environment using a stateful Path Computation Element (PCE) as a central controller. The obtained resultsdisclose that the cost-efficient node design parameter, namely, the size of the spatial group , depends on both the network and traffic profile size. Specifically, for a national optical backbone network equipped with a homogeneous and hexagonally arranged 6-weakly-coupled modes and 7-weakly-coupled cores fibers, equals 6, while for a continental backbone network, can raise up to 14. In any case, we demonstrate that the cost-benefit tradeoff in node design must be analyzed in detail in order to meet the huge traffic volumes of the next years.