Routine Direct Measurement of Arterial Pressure in Unanesthetized Rats

Weeks, James R.; Jones, J. A.

doi:10.3181/00379727-104-25937

Cited by 171 publications

(56 citation statements)

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“…The pressure transducers were zeroed at the mid-point of the thoracic cage in the supine. The abdominal aorta was cannulated by the modified method of Weeks and Jones (1960). A midline incision was made, and the abdominal aorta was exposed just above the iliac bifurcation.…”

Section: Methodsmentioning

confidence: 99%

Changes in Pulmonary Hemodynamics during Normoxia and Hypoxia in Awake Rats Treated with Intratracheal Bleomycin.

Sato

Kato

Arisaka

et al. 1993

Tohoku J. Exp. Med.

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Section: Methodsmentioning

confidence: 99%

Changes in Pulmonary Hemodynamics during Normoxia and Hypoxia in Awake Rats Treated with Intratracheal Bleomycin.

Sato

Kato

Arisaka

et al. 1993

Tohoku J. Exp. Med.

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“…Two and a half weeks before a study, each rat was anesthetized with 50 mg/kg i.p. of pentobarbital, and modified Weeks' catheters 18 were implanted in the abdominal aortae and vena cavae. Two weeks later, the rats were anesthetized and a cannula was ^surgically inserted into the urinary bladder.…”

Section: Methodsmentioning

confidence: 99%

Potentiation of renal effects of atrial natriuretic factor-(99-126) by SQ 29,072.

Seymour¹,

Fennell²,

Swerdel³

1989

Hypertension

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Depressor and renal activities of atrial natriuretic factor-(99-126) were determined in conscious, unrestrained spontaneously hypertensive rats treated with a neutral endopeptidase inhibitor, SQ 29,amino]heptanoic acid). SQ 29,072 (100 /tmol/kg i.v.) prolonged the transient depressor effects of the peptide for as long as 2 hours. During the first hour after 3, 10, and 30 nmol/kg atrial natriuretic factor, urinary excretion of cyclic 3'5' guanosine monophosphate was significantly increased by 9.2±3.4, 13.0±2.2, and 12.7±4.2 nmol/kg/hr, respectively, in vehicle-treated rats and by 26.9±7.9, 52.1±11.1, and 46.4±12.2 nmol/kg/hr, respectively, in rats given 100 /tmol/kg SQ 29,072. During the first hour after 3 and 10 nmol/kg atrial natriuretic factor-(99-126), the sodium loss was 161±56 and 139±42 /teq/kg/hr in vehicle-treated rats and was significantly greater (694±316 and l,038±135 /teq/kg/hr) in rats given 100 /tmol/kg SQ 29,072. After administration of 3, 10, and 30 /tmol/kg SQ 29,072, the area over the curves of the depressor responses to 3 nmol/kg of the peptide increased from 297±70 to 306±108, 440±143, and 669±186 mm Hgmin, respectively, while the concurrent natriuretic responses rose from 161±56 to 250±88,332±142, 464±164, and 694±316 /teq/kg/hr. In summary, the neutral endopeptidase inhibitor SQ 29,072 increased the magnitudes and especially the durations of the depressor, natriuretic, and cyclic guanosine monophosphate responses to exogenous atria] natriuretic factor-(99-126) in conscious spontaneously hypertensive rats, presumably by inhibition of degradation of atrial natriuretic factor in vivo. In conclusion, neutral endopeptidase inhibition offers an important new technique for enhancement and prolongation of the biological lifetime of atrial natriuretic factor. (Hypertension 1989;14:87-97)

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“…Test substances were injected through a cannula implanted in a jugular vein. Arterial cannulas were implanted under pentobarbitone-Na anaesthesia (50 mg/kg intraperitoneally) according to the method of Weeks & Jones (1960), 3-5 days before the experiment. At the same time, saline-filled, stoppered polyethylene tubing of 0.1 mm internal diameter was inserted into a jugular vein and led subcutaneously to the nape of the neck.…”

Section: Methodsmentioning

confidence: 99%

Antihypertensive Effects of Alpha‐methylated Catecholamine Analogues in the Rat*

Brunner

Hedwall

Maître

et al. 1967

British Journal of Pharmacology and Chemotherapy

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Routine Direct Measurement of Arterial Pressure in Unanesthetized Rats

Cited by 171 publications

References 0 publications

Changes in Pulmonary Hemodynamics during Normoxia and Hypoxia in Awake Rats Treated with Intratracheal Bleomycin.

Changes in Pulmonary Hemodynamics during Normoxia and Hypoxia in Awake Rats Treated with Intratracheal Bleomycin.

Potentiation of renal effects of atrial natriuretic factor-(99-126) by SQ 29,072.

Antihypertensive Effects of Alpha‐methylated Catecholamine Analogues in the Rat*

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