Routine genetic testing for thoracic aortic disease may levy high costs to patients with little benefit

Role of losartan in prevention of aortic dilatation in Marfan syndrome: A systematic review and meta-analysis

“…Many patients with aortic dilatation subsequently suffer from fatal aortic dissections, 1 which arise suddenly and are difficult to diagnose and treat preemptively. 2 Studies have shown that increased transforming growth factor β (TGF-β) signaling plays a role in the development of aortic dilatation. Based on this information, it was proposed that angiotensin receptor blockers (ARBs) could lower the incidence of aortic aneurysm given their ability to decrease TGF-β signaling.…”