2001
DOI: 10.1046/j.1537-2995.2001.41030333.x
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Routine HCV PCR screening of blood donations to identify early HCV infection in blood donors lacking antibodies to HCV

Abstract: HCV RNA detection by PCR can be carried out routinely in blood donor screening without significant delay of release of the components. The residual risk of transmission can be reduced by identification of early infection, which can lead to an improved safety of blood components. RNA screening can also be advantageous in cases of incomplete or lack of antibody response to HCV.

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Cited by 27 publications
(21 citation statements)
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“…HIV or HCV RNA was always negative in our sero-negative patients, demonstrating indirectly the speci®city of nucleic acid tests as described in healthy subjects [Albadalejo et al, 1998;Murphy et al, 2000]. Studies on transfusion-transmitted infection showed that several hundreds of thousands of patients must be tested to detect patients in the serological window [Schreiber et al, 1996;Roth et al, 1999;Hitzler and Runkel, 2001]. Thus, it is not surprising that no positive PCR was found in the sero-negative patients because of the relatively small number of donors.…”
Section: Discussionsupporting
confidence: 64%
See 1 more Smart Citation
“…HIV or HCV RNA was always negative in our sero-negative patients, demonstrating indirectly the speci®city of nucleic acid tests as described in healthy subjects [Albadalejo et al, 1998;Murphy et al, 2000]. Studies on transfusion-transmitted infection showed that several hundreds of thousands of patients must be tested to detect patients in the serological window [Schreiber et al, 1996;Roth et al, 1999;Hitzler and Runkel, 2001]. Thus, it is not surprising that no positive PCR was found in the sero-negative patients because of the relatively small number of donors.…”
Section: Discussionsupporting
confidence: 64%
“…Large-scale studies in transfusion have shown that sensitive nucleic acid tests for HIV and HCV could be positive in the absence of antibody and could therefore reduce the risk of virus transmission [Schreiber et al, 1996;Roth et al, 1999;Hitzler and Runkel, 2001]. Several countries have recommended recently nucleic acid tests on pooled plasma samples from blood donors.…”
Section: Introductionmentioning
confidence: 99%
“…29,30 In addition it is possible that some blood donors with HBV infection are being missed by current screening procedures and these may need to be reassessed. 31,32 A large proportion of patients had previously received blood transfusions. The risk of infection could therefore be further reduced by more effective management of anemia with iron supplementation and erythropoietin.…”
Section: Discussionmentioning
confidence: 99%
“…Prior to the introduction of effective screening of blood donors, blood transfusions were recognised as the leading source of HCV infection and some of these infections may have been acquired before adequate screening was introduced [21,40]. In addition it is possible that some blood donors with HCV infection are being missed by current screening procedures and these may need to be reassessed [42,43]. On the other hand the lack of association between blood transfusions and new infections suggests that fewer infections are acquired by this route than previously.…”
Section: Discussionmentioning
confidence: 99%