Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019

Abstract

The aim of this study was to determine the frequency of venous thromboembolism in critically ill coronavirus disease 2019 patients and associate a degree of inflammatory marker elevation to venous thromboembolism development.

D-dimers at hospital admission for COVID-19 are associated with in hospital mortality independently of venous thromboembolism: Insight from a French multicenter cohort study

“…Major confounding factor for D-dimers increase could be macrothrombosis since high incidence of VTE (PE or DVT) (7,9,27) (33,34) but in the present study, we only assessed D-dimers at admission. However, since VTE occurrence did not to modify in-hospital mortality in the present study, this lack of continuous monitoring of D-dimers is unlikely to modify results.…”

High Incidence of Venous Thromboembolism in Patients with Coronavirus Disease 2019: A Call for Improved Awareness and Prevention

“…Thirteen studies used lower-extremity venous ultrasound scanning or CTPA to con rm the diagnosis of VTE only in the presence of a clinical suspicion, and we prede ned this study group as the "suspected screening group." [1,[3][4][5][6][8][9][10][11][12][13][14][15] Seven studies routinely screened VTE in every patient using lower-extremity venous ultrasound scanning, and this study group was prede ned as the "routine screening group." [16][17][18][19][20][21][22] Our primary aim was to determine the incidence of VTE in COVID-19 patients in two prede ned cohort subtypes:…”

The Incidence of Pulmonary Thromboembolism in Critically Ill Patients With COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression of Observational Studies

“…We included 14 studies with a total of 1182 patients into this systematic review and meta-analysis. [12][13][14][15][16][17][18][19][20][21][22][23][24][25] A summary of study characteristics can be seen in Table 2, whereas a summary of patient characteristics can be seen in Table 3. [16,21] su cient information on anticoagulation practices, 100% of patients received at least prophylactic anticoagulation.…”

“…[12][13][14][15][16][17][18][19][20][21][22][23][24][25] A summary of study characteristics can be seen in Table 2, whereas a summary of patient characteristics can be seen in Table 3. [16,21] su cient information on anticoagulation practices, 100% of patients received at least prophylactic anticoagulation. [13, 14, 16, 18-22, 24, 25] In the study by Grandmaison et al, 93.1% of patients received at least prophylactic anticoagulation.…”

“…[15] Modality and indication for pulmonary thromboembolism imaging Contrast-enhanced computed tomographic scan was the principal modality used to diagnose PTE in all included studies. [12][13][14][15][16][17][18][19][20][21][22][23][24][25] Eight studies speci cally reported the indication for performing PTE imaging. [14-16, 19, 20, 22, 23, 25] All eight studies adopted a selective approach based on the patient's clinical condition to decide if PTE imaging was required.…”