Routinised and compulsive‐like behaviours in individuals with Down syndrome

Glenn, Sheila; Cunningham, Cliff; Nananidou, Angela; Glenholmes, Patricia

doi:10.1111/jir.12199

Cited by 19 publications

(15 citation statements)

References 25 publications

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“…A few studies have demonstrated similar findings with individuals with Down syndrome [8,10,28]. There are similar results for children with ASD [35,36].…”

Section: Methodsmentioning

confidence: 53%

“…Second, “Repetitive Behaviours” (including items such as “prefers the same household schedule or routine every day”, “acts out the same thing over and over in pretend play”). These two factors have been replicated in subsequent studies [6,7,8]. In addition, a few studies have found an additional factor of “Sensitivity to the environment” indexed by preference to certain articles of clothing (e.g., [6,8,9,10]).…”

Section: Methodsmentioning

confidence: 72%

“…These two factors have been replicated in subsequent studies [6,7,8]. In addition, a few studies have found an additional factor of “Sensitivity to the environment” indexed by preference to certain articles of clothing (e.g., [6,8,9,10]). All studies have found internal consistency and test-retest reliability of the CRI to be high and significant.…”

Section: Methodsmentioning

confidence: 72%

“…In relation to the question of pathology of RBRI, Glenn et al [8] studied 125 adults with Down syndrome aged 18 to 43 years assessed for mental health problems (Prasher, Glenn, Cunningham, Glenholmes, Arshad, and Kirby [30]). Parents or carers completed the CRI, and the Strengths and Difficulties Questionnaire [31] in order to get measures of worries and fears.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Repetitive Behaviours and Restricted Interests in Individuals with Down Syndrome—One Way of Managing Their World?

Glenn

2017

Brain Sciences

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This paper argues that the repetitive behaviour and restrictive interests (RBRI) displayed by individuals with Down syndrome have mostly positive functions. However, as research has developed from interests in Obsessional Compulsive Disorder or Autistic Spectrum Disorder, unfortunately a view has arisen that RBRI in individuals with Down syndrome are also likely to be pathological. This is particularly the case in adults. The paper reviews: (a) measures employed and the perspectives that have been used; (b) the development in typically developing individuals, those with Down syndrome, and those with other conditions associated with intellectual disability; (c) positive and possible negative effects of RBRI; and (d) the need for more research. The conclusion is that, for their level of development, RBRI are helpful for most individuals with Down syndrome.

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“…A few studies have demonstrated similar findings with individuals with Down syndrome [8,10,28]. There are similar results for children with ASD [35,36].…”

Section: Methodsmentioning

confidence: 53%

Section: Methodsmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Repetitive Behaviours and Restricted Interests in Individuals with Down Syndrome—One Way of Managing Their World?

Glenn

2017

Brain Sciences

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“…It would, therefore, be valuable to consider ASD in future studies. Moreover, routinized/repetitive behavior has been associated with worries/fears [60,61], and, as such, could relate to the increased frequency/severity of anxious symptoms (Section 1).…”

Section: Discussionmentioning

confidence: 99%

The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale: Comprehensive assessment of psychopathology in Down syndrome

Dekker

Deyn

2019

European Neuropsychopharmacology

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People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated. The central aim was to identify items that change in relation to the dementia status, and thus may differentiate between diagnostic groups. Structured interviews were conducted with informants of persons with DS without dementia (DS, n = 149), with questionable dementia (DS+Q, n = 65), and with diagnosed dementia (DS+AD, n = 67). First exploratory data suggest promising interrater, test-retest, and internal consistency reliability measures. Concerning item relevance, group comparisons revealed pronounced increases in frequency and severity in items of anxiety, sleep disturbances, agitation & stereotypical behavior, aggression, apathy, depressive symptoms, and eating/drinking behavior. The proportion of individuals presenting an increase was highest in DS+AD, intermediate in DS+Q, and lowest in DS. Interestingly, among DS+Q individuals, a substantial proportion already presented increased anxiety, sleep disturbances, apathy, and depressive symptoms, suggesting that these changes occur early in the course of AD. Future efforts should optimize the scale based on current results and clinical experiences, and further study applicability, reliability, and validity. Future application of the scale in daily care may aid caregivers to understand changes, and contribute to timely interventions and adaptation of caregiving.

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Toward better characterization of restricted and repetitive behaviors in individuals with germline heterozygous PTEN mutations

Uljarević

Frazier

Rached

et al. 2021

American J of Med Genetics Pt A

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This study aimed to further our understanding of restricted and repetitive behaviors (RRB) among individuals with germline pathogenic mutations in PTEN by providing multimethod characterization and comparison of key RRB subdomains across individuals with PTEN mutations with autism spectrum disorder (ASD) (PTEN‐ASD), with PTEN mutations without ASD (PTEN‐No ASD) and with ASD and macrocephaly but without PTEN mutations (Macro‐ASD). Of 86 total research participants, 38 had PTEN‐ASD (Mage = 8.93 years, SDage = 4.75), 25 Macro‐ASD (Mage = 11.99 years; SDage = 5.15), and 23 PTEN‐No ASD (Mage = 8.94 years; SDage = 4.85). The Repetitive Behavior Scale‐Revised (RBS‐R) and the Autism Diagnostic Interview‐Revised (ADI‐R) were used as measures of distinct RRB domains. There were significant group differences in the RBS‐R repetitive motor behaviors (RMB; F = 4.52, p = 0.014, ω2 = 0.08), insistence on sameness (IS; F = 4.11, p = 0.02, ω2 = 0.05), and circumscribed interests (CI; F = 7.80, p = 0.001, ω2 = 0.14) scales. Post hoc comparisons showed that the PTEN‐No ASD group had significantly lower RMB, IS, and CI scores compared to both PTEN‐ASD and Macro‐ASD groups. Importantly, PTEN‐No ASD group still showed elevated RRB levels. Furthermore, there was a portion of individuals in PTEN‐No ASD group whose Full‐Scale Intelligence Quotient (FSIQ) was >70 that did not show floor level scores in the RMB domain. After adjusting for age and FSIQ scores, group differences were no longer statistically significant. RMB, IS, and CI domains showed distinct association patterns with sex, age, and FSIQ. This investigation provides the largest and most comprehensive characterization of distinct RRB domains in individuals with PTEN mutations to date. Despite the limitations, our findings have important assessment and treatment implications.

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Routinised and compulsive‐like behaviours in individuals with Down syndrome

Cited by 19 publications

References 25 publications

Repetitive Behaviours and Restricted Interests in Individuals with Down Syndrome—One Way of Managing Their World?

Repetitive Behaviours and Restricted Interests in Individuals with Down Syndrome—One Way of Managing Their World?

The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale: Comprehensive assessment of psychopathology in Down syndrome

Toward better characterization of restricted and repetitive behaviors in individuals with germline heterozygous PTEN mutations

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