Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery

Boesing, Fernanda; Moreira, Emília Addison Machado; Wilhelm-Filho, Danilo; Vigil, Silvana Virgínia Gagliotti; Parizottto, Eduardo Bennedetti; Inácio, Déborah Bunn; Portari, Guilherme Vannucchi; Trindade, Erasmo B. S. M.; Jordão-Júnior, Alceu Afonso; Fröde, Tânia Sílvia

doi:10.1007/s11695-010-0196-x

Cited by 35 publications

(28 citation statements)

References 42 publications

(51 reference statements)

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“…Therefore, antioxidant enzymes are depleted in obesity and substrates such as GSH increase. These results corroborate the findings by Boesing et al, 35 who also found decreased GSH levels in obese patients after bariatric surgery.…”

Section: Figuresupporting

confidence: 92%

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Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method:We have assessed 16 morbidly obese women five days before and 180 days after the surgery. The control group comprised 16 non-obese women. Levels of thiobarbituric acid-reactive substances, carbonylated proteins, reduced glutathione and ascorbic acid were assessed in the patients' plasma. Results: Levels of lipid peroxidation and protein carbonylation in the pre-surgical obese women were higher than those of the controls and post-surgical obese women. Levels of reduced glutathione in the pre-surgical obese women were high compared to the controls, and declined after surgery. Levels of ascorbic acid fell in the pre--surgical obese women compared to the control and post-surgical obese women. Conclusion: Body weight influences the production of reactive oxygen species. Bariatric surgery, combined with weight loss and vitamin supplementation, reduces cellular oxidation, thus reducing tissue damage.

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Section: Figuresupporting

confidence: 92%

“…According to Vincent and Taylor, 37 obese individuals usually consume less fruits and vegetables, which are important sources of dietary antioxidants such as ASA. This result may be confirmed by Boesing et al and Kisakol et al, 35,38 who found an inverse correlation between BMI and ASA concentrations.…”

Section: Figuresupporting

confidence: 71%

Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

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“…Reductions in inflammatory markers such as CRP and IL-6 have even been observed after weight loss as little as 5% (Imayama et al, 2012), although Madsen et al (2008) found that over a 3-year period weight loss needed to exceed 10% to induce a significant improvement in inflammatory markers. Weight loss is also associated with reduced markers of oxidative stress such isoprostane, thiobarbituric acid reactive substances and malondialdehyde (Boesing et al, 2010, Bougoulia et al, 2006, Ozcelik et al, 2005, Wycherley et al, 2008, and increased antioxidant enzymes such as glutathione peroxidase and catalase (Boesing et al, 2010, Bougoulia et al, 2006.…”

Section: Does Weight Loss Improve Dysregulated Pathways Associated Wimentioning

confidence: 99%

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Lopresti

Drummond

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

196

128

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Rates of obesity are higher than normal across a range of psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the problem of obesity is generally acknowledged in mental health research and treatment, an understanding of their bi-directional relationship is still developing. In this review the association between obesity and psychiatric disorders is summarised, with a specific emphasis on similarities in their disturbed biological pathways; namely neurotransmitter imbalances, hypothalamus-pituitary-adrenal axis disturbances, dysregulated inflammatory pathways, increased oxidative and nitrosative stress, mitochondrial disturbances, and neuroprogression. The applicability and effectiveness of weight-loss interventions in psychiatric populations is reviewed along with their potential efficacy in ameliorating disturbed biological pathways, particularly those mediating inflammation and oxidative stress. It is proposed that weight loss may not only be an effective intervention to enhance physical health but may also improve mental health outcomes and slow the rate of neuroprogressive disturbances in psychiatric disorders. Areas of future research to help expand our understanding of the relationship between obesity and psychiatric disorders are also outlined.

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“…We identified 15 studies investigating the effect of weight loss interventions (diet- and/or exercise-, and surgery-induced) on individuals' oxidative stress level (table 1): 6 RCTs and 9 non-randomized intervention studies (n = 5 diet, n = 6 diet and/or exercise interventions, and n = 3 bariatric surgery interventions) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48].…”

Section: Resultsmentioning

confidence: 99%

“…All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. …”

Section: Resultsmentioning

confidence: 99%

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

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Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.

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Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery

Abstract: Roux-en-Y bypass gastroplasty led to decreased proinflammatory parameters together with increased nutritional antioxidants, catalase, and TBARS, and decreased GSH 6 months after surgery.

Cited by 35 publications

References 42 publications

Obesity, bariatric surgery and oxidative stress

Obesity, bariatric surgery and oxidative stress

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

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