Obesity is an epidemic in the developed world. In the U.S., over one-third of women are now obese, with significant adverse consequences for their reproductive and longterm health. Many of these women gain excessive weight in pregnancy and retain it postpartum, with an additive effect across multiple pregnancies. Maternal obesity is associated with an increased risk for miscarriage, congenital anomalies, stillbirth, gestational diabetes, preeclampsia, and cesarean section. Offspring of obese women are at increased risk for being large for gestational age and may be programmed for obesity and metabolic syndrome, thus perpetuating a cycle of obesity across generations. Certain alterations to routine prenatal care may be necessary for obese women in order to optimize obstetric and neonatal outcomes. Future research priorities should be aimed at understanding the biologic mechanisms underlying the adverse outcomes associated with maternal obesity and at developing effective interventions for this growing high-risk population.