2023
DOI: 10.1002/jat.4444
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Roxadustat induces hepatotoxicity in zebrafish embryos via inhibiting Notch signaling

Abstract: Roxadustat is a novel and effective small‐molecule inhibitor of hypoxia‐inducible factor prolyl hydroxylase (HIF‐PHI). However, little research has been done on its toxicity to vertebrate embryonic development. In this study, we used zebrafish to assess the effects of roxadustat on early embryonic development. Exposure to 14, 28, and 56 μM roxadustat resulted in abnormal embryonic development in zebrafish embryos, such as shortened body length and early liver developmental deficiency. Roxadustat exposure resul… Show more

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