Royal jelly causes hypotension and vasodilation induced by increasing nitric oxide production

Pan, Yongming; Rong, Yili; You, Mengmeng; Ma, Quanxin; Chen, Minli; Hu, Fuliang

doi:10.1002/fsn3.970

Cited by 21 publications

(23 citation statements)

References 35 publications

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“…Therefore, it is assumed that orally administered ACh is mostly degenerated in the process of absorption and blood transport before it reaches the ACh receptor expressed in brain cholinergic synapses and autonomously innervated organs, such as smooth muscles of blood vessels and intestines, pancreas, and LGs. Nevertheless, it has been reported that orally administered RJ has ACh-like effects, such as improvement of Alzheimer’s disease [ 35 ], vasodilation induced by nitric oxide production [ 36 ], and induction of insulin secretion [ 37 ]. Moreover, our previous report showed that RJ had a tear secretion capability via muscarinic acetylcholine receptor (mAChR) signaling induced by intracellular Ca 2+ increase in LGs, which was suppressed by the mAChR antagonist atropine and by inhibitors of phospholipase C and ER-Ca 2+ -ATPase essential enzyme pathways [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Yamaga¹,

Iwasaku

Tani³

et al. 2021

Nutrients

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Dry eye is a multifactorial disease characterized by ocular discomfort and visual impairment. Our previous studies have shown that royal jelly (RJ) has restored the capacity for tear secretion by modulating muscarinic calcium signaling. RJ contains acetylcholine, which is a major cholinergic neurotransmitter, and a unique set of fatty acids with C 8 to 12 chains, which are expected to be associated with health benefits. The purpose of the present study was to investigate the active components involved in tear secretion capacity, focusing on acetylcholine and fatty acids in RJ. Using the stress-induced dry-eye model mice, it was confirmed that acetylcholine with three fatty acids (10-hydroxydecanoic acid, 8-hydroxyoctanoic acid, and (R)-3,10-dihydroxydecanoic acid) was essential for tear secretion. In ex vivo Ca2+ imaging, these three fatty acids suppressed the decrease in intracellular modulation of Ca2+ in the lacrimal gland by acetylcholine when treated with acetylcholinesterase, indicating that the specific type of RJ fatty acids contributed to the stability of acetylcholine. To our knowledge, this study is the first to confirm that a specific compound combination is important for the pharmacological activities of RJ. Our results elucidate the active molecules and efficacy mechanisms of RJ.

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Section: Discussionmentioning

confidence: 99%

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Yamaga¹,

Iwasaku

Tani³

et al. 2021

Nutrients

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“…Furthermore, RJ could also increase NO production in cyclic guanosine monophosphate (cGMP) in isolated aortic rings. Anti-hypertensive activities of RJ are associated with NO production while muscarinic receptor agonists produced a vasodilation response by the NO/cGMP pathway and calcium channels [93]. RJ proteins have the potential to inhibit the angiotensin 1-converting enzyme's (ACE) activity produced by the gastrointestinal enzyme hydrolysis and reduce systolic blood pressure in the spontaneously hypertensive rats (SHR) [154].…”

Section: Anti-hypertension Effectmentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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“…A strong correlation between thyroid dysfunction and AD was demonstrated by 14 out of 23 studies [ 203 ]. Research documents an association of thyroid stimulating hormone and free triiodothyronine (T3) with regional cerebral blood flow in patients with MCI and AD [ 204 ].…”

Section: Mechanisms Underlying Effects Of Rj On Cognition and Ad-rmentioning

confidence: 99%

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Ali

2020

Antioxidants

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The astronomical increase of the world’s aged population is associated with the increased prevalence of neurodegenerative diseases, heightened disability, and extremely high costs of care. Alzheimer’s Disease (AD) is a widespread, age-related, multifactorial neurodegenerative disease that has enormous social and financial drawbacks worldwide. The unsatisfactory outcomes of available AD pharmacotherapy necessitate the search for alternative natural resources that can target various the underlying mechanisms of AD pathology and reduce disease occurrence and/or progression. Royal jelly (RJ) is the main food of bee queens; it contributes to their fertility, long lifespan, and memory performance. It represents a potent nutraceutical with various pharmacological properties, and has been used in a number of preclinical studies to target AD and age-related cognitive deterioration. To understand the mechanisms through which RJ affects cognitive performance both in natural aging and AD, we reviewed the literature, elaborating on the metabolic, molecular, and cellular mechanisms that mediate its anti-AD effects. Preclinical findings revealed that RJ acts as a multidomain cognitive enhancer that can restore cognitive performance in aged and AD models. It promotes brain cell survival and function by targeting multiple adversities in the neuronal microenvironment such as inflammation, oxidative stress, mitochondrial alterations, impaired proteostasis, amyloid-β toxicity, Ca excitotoxicity, and bioenergetic challenges. Human trials using RJ in AD are limited in quantity and quality. Here, the limitations of RJ-based treatment strategies are discussed, and directions for future studies examining the effect of RJ in cognitively impaired subjects are noted.

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Royal jelly causes hypotension and vasodilation induced by increasing nitric oxide production

Cited by 21 publications

References 35 publications

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

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