Royal jelly enhances antigen‐specific mucosal IgA response

Abstract

The effective uptake of antigens (Ags) by specialized M cells of gut‐associated lymphoid tissues is an important step in inducing an efficient intestinal mucosal immune response. In this study, royal jelly (RJ) was found to stimulate the differentiation of M‐like cells from human Caco‐2 cells in an in vitro M cell model. Furthermore, RJ and protease‐treated royal jelly (pRJ) efficiently enhanced transcytosis of FluoSpheres® carboxylate‐modified microspheres from the apical side to the basolateral side in the model. Therefore, we evaluated the ability of pRJ to induce efficient mucosal immune responses in an in vivo nonhuman primate. Continuous oral administration of commercially available pRJ resulted in a significant enhacement of the antigen‐specific IgA response in stool sample. Interestingly, Caco‐2 monolayer assay demonstrated that ether extracts from pRJ efficiently increased the expression level of a universal M cell marker, glycoprotein 2 (gp2). These findings suggest that pRJ exhibits mucosal immunomodulatory properties via stimulation of effective uptake of Ags through M cells.

Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota

“…The effective uptake of antigens mediated by intestinally associated lymphoid tissue-specific M cells is a key step in inducing an effective intestinal mucosal immune response. Protease-treated RJ was reported to promote antigen-specific mucosal IgA response and regulate mucosal immune activity by enhancing the uptake of antigens by M cells in Caco-2 cells [ 14 ].…”

Royal Jelly: Biological Action and Health Benefits

“…Increase in overall well-being and recuperation from fatigue and menopausal problems [90,121,202,211,223,224] Against stenocardia and after heart attack; arteriosclerosis and atherosclerosis; hypertension [187,188,190,195,197,[202][203][204] Against respiratory system diseases, asthma [333,338,339] Against diseases the eye, e.g., blepharitis, conjunctivitis and retina burns, circulatory disorders in the eye [97,126,161] Bio-stimulating effect, increases physical endurance and work ability and increases resistance to hypoxia [52,124,125,152] Increase memory, neuro-vegetative activation [137,138,141,145,147,154,157 RJ has been used for a long time. The first recommendation for its use in human therapy dates from 1922 in France.…”

“…It is also interesting to note that protease-treated RJ can promote an antigen-specific mucosal IgA response by enhancing the uptake of antigens by M cells, increasing the efficacy of the immune response of the intestinal mucosa [ 339 ].…”

Exploring the Potential of Bee-Derived Antioxidants for Maintaining Oral Hygiene and Dental Health: A Comprehensive Review

“…Various studies have explained the unique bioactive components of honey bee products that confer therapeutic and medicinal properties and improve the overall health. The bioactive compounds found in honey, propolis and royal jelly are known to possess antioxidant, anti-microbial, anti-inflammatory, anti-cancer, anti-ulcer, immunomodulatory, neuromodulatory and metabolic syndrome preventing activities [24][25][26][27][28][29][30][31][32][33][34][35][36]. Due to these properties, these products are being used/or show wide applications in preventing oral diseases like stomatitis, mouth ulcers, dental caries, plaque, gingivitis, periodontitis, cavity infection, dentin hypersensitivity, oral cancer, malodor and mucositis [15,[37][38][39][40].…”