Royal jelly has estrogenic effects in vitro and in vivo

Mishima, Satoshi; Suzuki, K; Isohama, Yoichiro; Kuratsu, Naoko; Araki, Yasufumi; Inoue, Makoto; Miyata, Takeshi

doi:10.1016/j.jep.2005.04.012

Cited by 118 publications

(106 citation statements)

References 16 publications

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“…Recent studies showed both estrogenic (Mishima et al, 2005) and androgenic-like effect of drone food (Yucel et al, 2011). The androgeniclike effect seems to be related to the methyl palmitate and methyl oleate as active compounds found in the drone food (Seres et al,2013).…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Mărgăoan¹,

Mărghitaș²,

Dezmirean³

et al. 2017

BUASVMCN-ASB

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Given their beneficial effects in terms of health, the natural products, especially beehive products, have drawn the attention of consumers since long time ago. In order to guarantee the quality of these products on the market, their chemical composition needs to be analyzed. Thus, this current research had as objective the establishment of quality parameters for beehive brood food derived products: apilarnil and queen bee larvae triturate. These two products were compared with royal jelly which is the basis of brood food in the first 3 days of larval stage. The carbohydrates were determined by HPLC-IR and allowed the identification of seven carbohydrate compounds, predominantly glucose, fructose and sucrose. The lipid profile was analyzed by the Soxhlet method. The total protein content was determined by the Kjeldahl method. Free amino acids were analyzed by LC-MS. A total of 31 amino acids were identified of which nine are essential amino acids for humans.

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Section: Introductionmentioning

confidence: 99%

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Mărgăoan¹,

Mărghitaș²,

Dezmirean³

et al. 2017

BUASVMCN-ASB

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“…RJ is characterized by plethora of health beneficial properties showing antimetastatic action [2], antioxidative [3][4][5][6][7], hypoglycemic and immunological activities [8], cholesterol-lowering effects as well as estrogenic [9,10] and anti-fatigue features [11].…”

Section: Introductionmentioning

confidence: 99%

Insights into the infrared and Raman spectra of fresh and lyophilized royal jelly and protein degradation IR spectroscopy study during heating

Lazarevska

Makreski

2015

Maced. J. Chem. Chem. Eng.

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In terms of chemical composition, a honeybee secretion known as royal jelly (RJ) is very complex product containing water, proteins, carbohydrates, lipids, mineral salts and small amounts of polyphenols, vitamins and enzymes. Despite its chemical diversity, the bands originating from vibrational modes of the present proteins were successfully assigned in 1800-1200 cm -1 (Raman and IR) region where the interference of bands from other vibrational species is not substantial. The protein bands were attributed to amide I, amide II and amide III modes and their intensities, additionally, enabled to determine the protein secondary structures. The remaining bands up to 4000 cm -1 were attributed to other group vibrations whereas the region below 1200 cm -1 comprises bands from complex interacting modes within the major RJ components that can not be unequivocally attributed to distinct modes. The work also represents a pioneering effort to collect and interpret the Raman spectrum of fresh and lyophilized RJ samples and to correlate and describe the observed similarities/differences between IR and Raman spectra.Keywords: royal jelly; infrared; Raman spectra; band assignments; protein degradation УВИД ВО ИНФРАЦРВЕНИТЕ И РАМАНСКИТЕ СПЕКТРИ НА СВЕЖ И ЛИОФИЛИЗИРАН МАТИЧЕН МЛЕЧ И СТУДИЈА ЗА ПРОТЕИНСКАТА ДЕГРАДАЦИЈА ПРИ ЗАГРЕВАЊЕ СЛЕДЕНА СО ИНФРАЦРВЕНА СПЕКТРОСКОПИЈАМатичниот млеч (ММ), кој претставува пчелин секрет, има комплексен хемиски состав и содржи: вода, протеини, јаглехидрати, масти, минерални соли и мало количество полифеноли, витамини и ензими. И покрај разновидноста во хемискиот состав, инфрацрвените и раманските ленти кои потекнуваат од присутните протеини беа успешно асигнирани во подрачјето од 1800 до 1200 cm -1 . Тоа се должи на фактот што во оваа област интерференцијата, изразена преку преклопување на ленти од другите хемиски ентитети, е незначителна. Протеинските ленти беа припишани на модовите амид I, амид II и амид III, а интензитетите на лентите дополнително овозможија определување на секундарните структури на протеините. Другите спектрални ленти регистрирани до 4000 cm -1 беа асигнирани на други групови вибрации, додека во областа под 1200 cm -1 не може да се направи еднозначна интерпретација на спектрите поради силното преклопување помеѓу вибрационите ленти од многуте пристутни хемиски конституенти во ММ. Оваа студија претставува пионерски обид да се добијат и интерпретираат раманските спектри на свеж и лиофилизиран ММ како и да се корелираат и објаснат детектираните спектрални сличности/разлики помеѓу инфрацрвените и раманските спектри.Клучни зборови: матичен млеч; инфрацрвен; рамански спектар; асигнација на ленти; протеинска деградација  Dedicated to Academician Gligor Jovanovski on the occasion of his 70 th birthday. S. Lazarevska, P. MakreskiMaced. J. Chem. Chem. Eng. 34(1), 87-93 (2015) 88

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“…Royal jelly solution slightly inhibited the proliferation of MCF-7 cells. A recent report indicates that royal jelly has estrogenic activities through interaction with estrogen receptors (ER), 10) but the royal jelly obtained from the Yamada Apiculture Center did not enhance the proliferation of MCF-7 cells. It is possible that there are differences in components between the royal jelly used here and other samples.…”

mentioning

confidence: 99%

Effect of Royal Jelly on Bisphenol A-Induced Proliferation of Human Breast Cancer Cells

Nakaya

Onda

Sasaki

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Royal jelly has estrogenic effects in vitro and in vivo

Cited by 118 publications

References 16 publications

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Comparative Study on Quality Parameters of Royal Jelly, Apilarnil and Queen Bee Larvae Triturate

Insights into the infrared and Raman spectra of fresh and lyophilized royal jelly and protein degradation IR spectroscopy study during heating

Effect of Royal Jelly on Bisphenol A-Induced Proliferation of Human Breast Cancer Cells

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