RP-HPLC analysis of phenolic compounds, quantitative assessment of phytochemicals, antioxidant, analgesic, and anti-inflammatory potential of Cucumis melo var. inodorus fruit growing in Algeria

Barghout, Nihed; Djidel, Saliha; Bouaziz, Amel; Bentahar, Assia; Dahamna, Saliha; khennouf, Seddik

doi:10.1007/s11694-024-02769-3

Food Measure

2024

DOI: 10.1007/s11694-024-02769-3

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RP-HPLC analysis of phenolic compounds, quantitative assessment of phytochemicals, antioxidant, analgesic, and anti-inflammatory potential of Cucumis melo var. inodorus fruit growing in Algeria

Nihed Barghout,

Saliha Djidel,

Amel Bouaziz

et al.

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2024

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Antioxidant, anticoagulant and antithrombotic properties of ethanolic extract of Centaurea diluta subsp. algeriensis (Coss. & Durieu) Maire: in vitro study and novel therapeutic approach

Bouaziz,

Djidel,

Makhlouf

et al. 2024

S. F. J. of Dev.

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The aim of this study is to estimate the antioxidant, anticoagulant and antithrombotic activities of the ethanolic extract of Centaurea diluta subsp. Algeriensis (Coss. & Durieu) Maire, an endemic Algerian plant belonging to Asteraceae family. The antioxidant activity was determined by DPPH radical scavenging activity and metal chelating test. The plasma of healthy volunteers was used to evaluate the clotting time, prothrombin time, and thrombolysis activity. C. diluta ethanolic extract (CEE) showed a good ability to scavenge DPPH radical with an IC50 value of 0.115 ±0.005 mg/ml. In addition, this extract exhibited a high iron chalating capacity with IC50 of 0.36 ± 0.07 mg / ml. Also, the results showed that CEE exhibited anticoagulant activity by prolonging the clotting time at the concentration of 50 mg/ml. For prothrombin time, the concentration of 50 mg/ml has a strong effect with value of 13.14±1.91 sec. In the thrombolysis test, the CEE extract showed a moderate thrombolytic activity with the best effect at a concentration of 50 mg/ml (20.86±0.31%).These findings could pave the way for the development of natural antioxidant and anticoagulant agents that can be used in the prevention and treatment of thrombotic disorders.

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Antioxidant, anticoagulant and antithrombotic properties of ethanolic extract of Centaurea diluta subsp. algeriensis (Coss. & Durieu) Maire: in vitro study and novel therapeutic approach

Bouaziz,

Djidel,

Makhlouf

et al. 2024

S. F. J. of Dev.

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RP-HPLC analysis of phenolic compounds, quantitative assessment of phytochemicals, antioxidant, analgesic, and anti-inflammatory potential of Cucumis melo var. inodorus fruit growing in Algeria

Cited by 1 publication

References 45 publications

Antioxidant, anticoagulant and antithrombotic properties of ethanolic extract of Centaurea diluta subsp. algeriensis (Coss. & Durieu) Maire: in vitro study and novel therapeutic approach

Antioxidant, anticoagulant and antithrombotic properties of ethanolic extract of Centaurea diluta subsp. algeriensis (Coss. & Durieu) Maire: in vitro study and novel therapeutic approach

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