2023
DOI: 10.37022/jis.v6i1.52
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RP-HPLC method for analytical method development and validation of multi-kinase inhibitor

Abstract: This study was set out to create an RP-HPLC system that is effective, sensitive, picky, precise, accurate and practical. For this, a UV detection technique for detecting Sorafenib tosylate-loaded solid lipid nanoparticles has been developed and validated. To improve the procedure, many parameters were used (pH and Column). The chromatographic separation was carried out using a Shimadzu prominence-i LC-2030C and a C8 short column (5 m 4.6 x 100 mm). With a runtime of 10 minutes, 10 mL injection volume was maint… Show more

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