High-resolution satellite images must undergo a geometric rectification process in order to be used for metrical purposes. This operation, called orthorectification, is necessary because of deformations mainly due to camera distortions and acquisition geometry. To correctly orthorectify an image, it is necessary to accurately reconstruct the photogrammetric-acquisition characteristics and the image position with respect to a reference system connected to the ground. This operation, called orientation, can be done using various mathematical models such as rigorous, rational polynomial function (RPF), and rational polynomial coefficient, or, according to some authors, rapid positioning coefficient (RPC) models. Orientation and orthorectification are usually performed within specific commercial software, but in QGIS, these complex operations can be performed using the open libraries of the Orfeo Tool Box (OTB). Unfortunately, instructions given by OTB developers lead to scarce results. In fact, the procedure proposed in OTB does not allow for the full exploitation of the potential of RPC models, on which OTB itself is based. As OTB is open-source software, a plugin was developed to overcome these limitations and exploit its full potential. In fact, OTB interfaces are unfortunately essential, and some necessary functions are missing. Therefore, a new QGIS plugin was developed in order to run the entire process in the most photogrammetrically and statistically correct way, and, at the same time, to simplify the relative procedures.