RPE Curvature Can Screen for Early and Intermediate AMD

Cheung, Rene; Trinh, Matt; Tee, Yoh Ghen; Nivison-Smith, Lisa

doi:10.1167/iovs.65.2.2

Cited by 2 publications

(1 citation statement)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, similar measurements can be applied to other retinochoroidal boundaries such as the inner limiting membrane, retinal pigment epithelium (RPE), and CSI, including their ratios. Hence, our technique can extend beyond myopia to assess idiopathic macular hole [31], irregular RPE curvature in age-related macular degeneration [32], and ONH shape, crucial in myopia and glaucoma [33], all central themes for future research.…”

Section: Discussionmentioning

confidence: 99%

New findings on the unique curvature region in the posterior eye using widefield OCT

Hiraoka,

Tamura,

Moriguchi

et al. 2024

Preprint

View full text Add to dashboard Cite

This study aimed to explore the curvature distribution in the posterior eye among school-aged children using distortion-corrected optical coherence tomography (OCT) images and its relationship with biometric variables and choroidal vascular parameters. We conducted a prospective, observational, cross-sectional study involving 88 children aged 6 to 15 years. After comprehensive ocular examinations, widefield OCT volumes with a 68×68 degrees were captured utilizing a high-speed, wide-field SS-OCT prototype system. The distortion of the captured OCT volume was geometricallycorrected, and Gaussian curvature maps were derived from Bruch’s membrane segmentation lines. The mean curvature was assessed across four square regions of 19×19 degrees each, where axial length (AL), refractive error, age, and choroidal thickness (ChT) were statistically analyzed. Additionally, the entry site of the long posterior ciliary artery (LPCA) into the choroid were assessed from the same OCT volume. Analysis of 169 OCT images demonstrated bilateral symmetry in choroidal vascular patterns and posterior eye curvature. Mean curvature exhibited asignificant correlation with AL, refractive error, and ChT in the superior, macular, and inferior regions. Conversely, the temporal region showed a weak negative correlation. Notably, a local maximum curvature point was commonly observed in the temporal region for the first time in this study, suggesting a potential reversal of correlation in this area. The rationale for this observation remains unclear; however, the proximity of the local maximum curvature point to the long posterior ciliary artery (LPCA) entry site may suggest a link. Further investigation is necessary to elucidate the origins and implications of these findingsfor ocular development.

show abstract

Section: Discussionmentioning

confidence: 99%

New findings on the unique curvature region in the posterior eye using widefield OCT

Hiraoka,

Tamura,

Moriguchi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration

Cheung,

Trinh,

Nivison-Smith

2024

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose Outer retinal band integrity strongly predicts late age-related macular degeneration (AMD). However, it is often assessed subjectively as “continuity” using inconsistent definitions. Alternatively, “curvature” of the outer retinal bands is a quantitative metric that strongly correlates with AMD biomarkers and can screen for intermediate AMD. We evaluated the prognostic ability of retinal pigment epithelium (RPE) and ellipsoid zone (EZ) curvature for late AMD against outer retinal band continuity, pigmentary abnormalities, reticular pseudodrusen, and drusen volume. Methods Consecutive patients with intermediate AMD who progressed to late AMD ( n = 17) or remained stable ( n = 42) were recruited. RPE and EZ curvature were quantified as a ratio of their lengths over Bruch's membrane using the sinuosity method of assessing river curvature, where a ratio of ∼1 indicates no outer retinal pathology. RPE, EZ, and Bruch's membrane were manually segmented and their lengths automatically extracted. The primary outcomes were outer retinal sinuosity and the odds ratio of predicting late AMD. Results Mean follow-up time for progressors and nonprogressors was 4.4 and 3.6 years. RPE sinuosity was strongly associated with pigmentary abnormalities ( P = 0.001) and drusen volume ( P = 0.004) but not reticular pseudodrusen ( P = 0.28). RPE sinuosity >1.03 was the strongest predictor of late AMD developing within 5 years (15 [2.9–75]) and across the study period (25 [2.3-282]). Drusen volume >0.03 mm 3 was the strongest predictor of progression within 2 years (33 [2.5–426]), and RPD could not independently predict progression within any time frame. Conclusions RPE curvature is a promising, quantitative outer retinal biomarker that can prognosticate late AMD and potentially enhance prognostic models.

show abstract

RPE Curvature Can Screen for Early and Intermediate AMD

Cited by 2 publications

References 62 publications

New findings on the unique curvature region in the posterior eye using widefield OCT

New findings on the unique curvature region in the posterior eye using widefield OCT

Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration

Contact Info

Product

Resources

About