2023
DOI: 10.3892/or.2023.8670
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RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells

Macheng Lu,
Xingqian Hu,
Cong Cheng
et al.

Abstract: Ribosome production factor 2 homolog (RPF2) plays an important role in the life processes of ribosomal biogenesis; however, the function and mechanism of RPF2 in tumors are unclear. The present study demonstrated that RPF2 expression is involved in chemoresistance in colorectal cancer (CRC) cells. The current study demonstrated that upregulation of RPF2 expression in CRC promoted resistance to chemotherapeutic agents in CRC cells, whereas knockdown of RPF2 leads to increased sensitivity of CRC to chemotherapy.… Show more

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“…33,34 RPF2 can promote chemotherapy resistance in colorectal cancer cells. 35 There are many reports on CD151 and tumors, which not only play a core role in tumor progression, but also play a significant role in the immune microenvironment of tumors. Specifically, it can inhibit the movement of prostate cancer tumor cells during aggregation and regulate tumor occurrence by regulating communication between tumor cells and endothelial cells.…”
Section: Discussionmentioning
confidence: 99%
“…33,34 RPF2 can promote chemotherapy resistance in colorectal cancer cells. 35 There are many reports on CD151 and tumors, which not only play a core role in tumor progression, but also play a significant role in the immune microenvironment of tumors. Specifically, it can inhibit the movement of prostate cancer tumor cells during aggregation and regulate tumor occurrence by regulating communication between tumor cells and endothelial cells.…”
Section: Discussionmentioning
confidence: 99%