2023
DOI: 10.1101/2023.10.26.564249
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RpoS activates formation ofSalmonellaTyphi biofilms and drives persistence in the gall bladder

Stuti K. Desai,
Yiyang Zhou,
Rahul Dilawari
et al.

Abstract: The development of strategies for targeting the asymptomatic carriage of Salmonella Typhi in chronic typhoid patients has suffered owing to our basic lack of understanding of the molecular mechanisms that enable the formation of S. Typhi biofilms. Traditionally, studies have relied on cholesterol-attached biofilms formed by a closely related serovar, Typhimurium, to mimic multicellular Typhi communities formed on human gallstones. In long-term infections, S. Typhi adopts the biofilm lifestyle to persist in viv… Show more

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