RS 56 Characterization of NK1 receptor antagonists on pulpal hemodynamics in cats

Local application of NK1 receptor antagonists and pulpal blood flow in cat

“…The same result was shown in the study of Kim et al 10) . This vasodilatory function of SP in the dental pulp was confirmed in the present study and in the previous studies 10,17,32) and this finding supports that SP plays an important role of vasodilation in neurogenic inflammation.…”

“…SP injection caused dosedependant increases in PBF of unilaterally denervated cats and the magnitude of the responses was several folds larger than that of control side. In the study of Kim et al 17) , intra-arterial injection of NK1 receptor agonist, [Sarcosine]-SP, resulted in significant increase of PBF in a dosedependant manner. The same result was shown in the study of Kim et al 10) .…”

“…SP was titrated to exert maximum effect on PBF without influencing systemic blood pressure in order to minimize or eliminate the systemic effect. To compare the effects of drugs on 17) . These NK1 receptor antagonists were applied iontophoretically into the dentinal cavity at doses of 0.2�3.4 mM.…”

“…Of the natural agonists, SP has the highest affinity for NK1, NKA for NK2, and NKB for NK3 16) . NK1 agonist is already identified as SP and it is one of the most important neuropeptide involved in the hemodynamics and neurogenic inflammation in the dental pulp 17) .…”

“…Studies for the roles of SP include those for resting interstitial fluid pressure 11) , for the basal blood flow of pulp and gingiva 18) , and for the function of SP in pain transmission and the vascular system in various organs of animals 9) , and NK1 receptor antagonists were characterized 17) . Studies for the control of SP-induced responses include those in blocking the SP-induced responses such as the change in the blood flow, tissue pressure and vascular permeability 11) , its associated jaw-opening reflex [19][20][21] , in blocking responses elicited by noxious stimulus 9,22) .…”