rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 percent greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

Polygenic risk score for predicting weight loss after bariatric surgery

“…been observed in previous studies (25)(26)(27)(28). In this regard, the main distinctive feature of the present study resides in its use of genome-wide BMI-associated SNPs, which a priori should warrant an eventual impact of polygenic risk scores on weight loss dynamics.…”

The impact of family members on weight loss after sleeve gastrectomy

“…A minor allele at the FTO rs16945088 locus was found to be associated with less weight loss after bariatric surgery [13]. In another study, single-nucleotide polymorphism rs4771122 in an intron of MTIF3 was significantly associated with better weight loss after bariatric surgery [14]. The current evidence is mixed and inconclusive, and it is possible that the genes involved in weight loss and regain are different from those identified as obesity genes in crosssectional studies [13].…”

Good weight loss responders and poor weight loss responders after Roux-en-Y gastric bypass: clinical and nutritional profiles

“…Also the genetic factors and epigenetic mechanisms have been associated with variability in weight loss in response to surgical intervention (23). Polymorphisms in genes related to RYGB response after 1 year post-surgery were identified (24).…”