rSPECT: A compact gamma camera based SPECT system for small-animal imaging

Lage, Eduardo; Villena, Jose L.; Tapias, G.; Vidal-Migallon, I.; Abella, Mónica; Sisniega, Alejandro; Martinez, Naira P.; Ros, Domènec; Desco, Manuel; Vaquero, J.J.

doi:10.1109/nssmic.2009.5401682

Cited by 3 publications

(7 citation statements)

References 26 publications

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“…We used the same parallel-hole collimator that is used for small animal SPECT system [37]. This was a low-energy high-resolution parallel-hole collimator (LEHR) made of lead.…”

Section: Configuration Of Small Animal Spect Systemsmentioning

confidence: 99%

“…The spatial resolution and sensitivity values for a centered source in air, positioned 10, 20, 30, 40, and 50 mm from the collimator, were obtained. The FWHM of the point spread function (PSF) was determined by fitting a Gaussian function of the count profiles and by direct calculation from the profile data using a linear interpolation between the points above and below the half-maximum value [2,37]. To more accurately determine the resolution at each position, we repeated the measurements five times at each position.…”

Section: Comparison Of System Characteristicsmentioning

confidence: 99%

“…To more accurately determine the resolution at each position, we repeated the measurements five times at each position. The sensitivity, defined as the number of detected events divided by the number of emitted events, was evaluated [2,37]. The energy acceptance window was set at ± 10% (±14 keV) to reduce noise effects.…”

Section: Comparison Of System Characteristicsmentioning

confidence: 99%

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Feasibility of a CdTe-based SPECT for high-resolution low-dose small animal imaging: a Monte Carlo simulation study

Park¹,

Yu²,

Lee³

et al. 2014

J. Inst.

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Dedicated single-photon-emission computed tomography (SPECT) systems based on pixelated semiconductors such as cadmium telluride (CdTe) are in development to study small animal models of human disease. In an effort to develop a high-resolution, low-dose system for small animal imaging, we compared a CdTe-based SPECT system and a conventional NaI(Tl)based SPECT system in terms of spatial resolution, sensitivity, contrast, and contrast-to-noise ratio (CNR). In addition, we investigated the radiation absorbed dose and calculated a figure of merit (FOM) for both SPECT systems. Using the conventional NaI(Tl)-based SPECT system, we achieved a spatial resolution of 1.66 mm at a 30 mm source-to-collimator distance, and a resolution of 2.4-mm hot-rods. Using the newly-developed CdTe-based SPECT system, we achieved a spatial resolution of 1.32 mm FWHM at a 30 mm source-to-collimator distance, and a resolution of 1.7-mm hot-rods. The sensitivities at a 30 mm source-to-collimator distance were 115.73 counts/sec/MBq and 83.38 counts/sec/MBq for the CdTe-based SPECT and conventional NaI(Tl)-based SPECT systems, respectively. To compare quantitative measurements in the mouse brain, we calculated the CNR for images from both systems. The CNR from the CdTe-based SPECT system was 4.41, while that from the conventional NaI(Tl)-based SPECT system was 3.11 when the injected striatal dose was 160 Bq/voxel. The CNR increased as a function of injected dose in both systems. The FOM of the CdTe-based SPECT system was superior to that of the conventional NaI(Tl)-based SPECT system, and the highest FOM was achieved with the CdTe-based SPECT at a dose of 40 Bq/voxel injected into the striatum. Thus, a CdTe-based SPECT system showed significant improvement in performance compared with a conventional system in terms

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“…We used the same parallel-hole collimator that is used for small animal SPECT system [37]. This was a low-energy high-resolution parallel-hole collimator (LEHR) made of lead.…”

Section: Configuration Of Small Animal Spect Systemsmentioning

confidence: 99%

Section: Comparison Of System Characteristicsmentioning

confidence: 99%

Section: Comparison Of System Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility of a CdTe-based SPECT for high-resolution low-dose small animal imaging: a Monte Carlo simulation study

Park¹,

Yu²,

Lee³

et al. 2014

J. Inst.

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“…Additionally, a signal of DT cycles duration is generated at the BUSY output of this component in order to disable the associated stabilizer components during the processing of the current event. For the implementation of a SPECT system called rSPECT (Lage et al 2009b), we used the same components shown in figure 5 Each ADC module contain 16 channels (12 bit per channel) whose internal topology groups the channels in sets of 4 with an independent gate input for each of them. These ADC boards are prepared to work almost independently since they only need the gate signal to start the data acquisition, conversion and transmission.…”

Section: Data Acquisition System Prototypementioning

confidence: 99%

Data acquisition electronics for gamma ray emission tomography using width-modulated leading-edge discriminators

Lage¹,

Tapias²,

Villena³

et al. 2010

Phys. Med. Biol.

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We present a new high-performance and low-cost approach for implementing radiation detection acquisition systems. The basic elements used are chargeintegrating ADCs and a set of components encapsulated in an HDL (hardware definition language) library which makes it possible to implement several acquisition tasks such as time pickoff and coincidence detection using a new and simple trigger technique that we name WMLET (width-modulated leading-edge timing). As proof of concept, a 32-channel hybrid PET/SPECT acquisition system based on these elements was developed and tested. This demonstrator consists of a master module responsible for the generation and distribution of trigger signals, 2 × 16-channel ADC cards (12-bit resolution) for data digitization and a 32-bit digital I/O PCI card for handling data transmission to a personal computer. System characteristics such as linearity, maximum transmission rates or timing resolution in coincidence mode were evaluated with test and real detector signals. Imaging capabilities of the prototype were also evaluated using different detector configurations. The performance tests showed that this implementation is able to handle data rates in excess of 600k events s −1 when acquiring simultaneously 32 channels (96-byte events). ADC channel linearity is >98.5% in energy quantification. Time resolution in PET mode for the tested configurations ranges from 3.64 ns FWHM to 7.88 ns FWHM when signals from LYSO-based detectors are used. The measured energy resolution matched the expected values for the detectors evaluated and single elements of crystal matrices can be neatly separated in the acquired flood histograms.

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“…Al igual que en el capítulo anterior, se han añadido un anexo (Anexos 5.1) que contiene una comparativa del sistema SPECT desarrollado con otros sistemas comerciales. Este capítulo está basado en Lage et al, 2009d;Lage et al, 2009e;Lage et al, 2009f).…”

Section: Aunque En Los úLtimos Años Grandes Casas Comerciales Como Ge...unclassified

Sistemas tomográficos multimodalidad para animales de laboratorio

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rSPECT: A compact gamma camera based SPECT system for small-animal imaging

Cited by 3 publications

References 26 publications

Feasibility of a CdTe-based SPECT for high-resolution low-dose small animal imaging: a Monte Carlo simulation study

Feasibility of a CdTe-based SPECT for high-resolution low-dose small animal imaging: a Monte Carlo simulation study

Data acquisition electronics for gamma ray emission tomography using width-modulated leading-edge discriminators

Sistemas tomográficos multimodalidad para animales de laboratorio

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