RSV hospitalization in infancy increases the risk of current wheeze at age 6 in late preterm born children without atopic predisposition

Korsten, Koos; Blanken, Maarten O; Buiteman, Brigitte J.M.; Nibbelke, Elisabeth E.; Naaktgeboren, Christiana A.; Bont, Louis; Wildenbeest, Joanne G

doi:10.1007/s00431-018-03309-0

Cited by 19 publications

(15 citation statements)

References 31 publications

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“…Further analysis revealed that RSVH was the single most important factor for recurrent wheezing (OR: 4.40; p < 0.001) [47]. Similar results have been reported in the Dutch RISK study [51]. At the 6-year follow-up of this birth cohort of 2210 32-35 wGA infants, the current wheezing rate was 27.7% for RSVH cases and 17.6% for non-hospitalized infants (OR: 1.8; 95% CI: 1.11-2.85).…”

Section: Figuresupporting

confidence: 82%

“…At the 6-year follow-up of this birth cohort of 2210 32-35 wGA infants, the current wheezing rate was 27.7% for RSVH cases and 17.6% for non-hospitalized infants (OR: 1.8; 95% CI: 1.11-2.85). RSVH was found to be an independent risk factor for current wheezing at 6 years in children without atopic predisposition (OR: 4.1; 95% CI: 1.22-12.52) [51]. Other studies have reported higher healthcare resource utilization (including emergency department visits, outpatient visits, and hospitalizations) in late preterm infants in the year following RSV LRTI compared to their counterparts without such an infection [52,53].…”

Section: Figurementioning

confidence: 96%

“…As a consequence of RSVH, preterm infants may develop longer-term morbidities, such as recurrent wheezing [47][48][49][50][51]. In the SPRING study, a multicenter, observational, nested, case-control study undertaken in Spain, 32-35 wGA infants with RSVH (n = 125) had a significantly higher incidence of recurrent wheezing through the first 6 years of life, independent of familial or childhood atopy, compared to infants born at the same GA without RSVH (n = 362) (66.7 vs. 49.2%, respectively; p = 0.001) [47].…”

Section: Figurementioning

confidence: 99%

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Resolving the Debate on RSV Prophylaxis in Late Preterm Infants

Paes¹,

Rodgers‐Gray²,

Carbonell‐Estrany³

2019

The Burden of Respiratory Syncytial Virus Infection in the Young

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There is still active debate in the scientific literature about the importance of providing respiratory syncytial virus (RSV) prophylaxis to late preterm infants born at 33-35 weeks' gestational age (wGA). The American Academy of Pediatrics and the Canadian Paediatric Society position statements only advocate for RSV prophylaxis for infants <30 wGA. Several publications prove the contrary, reporting substantial morbidity and even mortality in older GA infants, following RSV infection. Consequently, other Societies, such as from Spain and Italy, have different criteria, and include as candidates 30-32 wGA infants and 33-35 wGA infants with risk factors for severe RSV disease. This chapter will systematically examine the current evidence for RSV prophylaxis in both early and late preterm infants 29-35 wGA and the cost-effectiveness of this strategy with the use of risk scoring tools. The authors will attempt to reconcile the misconception that late preterm infants do not merit RSV prophylaxis and hopefully resolve the long-standing debate that currently exists in many countries worldwide.

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Section: Figuresupporting

confidence: 82%

Section: Figurementioning

confidence: 96%

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Resolving the Debate on RSV Prophylaxis in Late Preterm Infants

Paes¹,

Rodgers‐Gray²,

Carbonell‐Estrany³

2019

The Burden of Respiratory Syncytial Virus Infection in the Young

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“…One previous study 3 found upper respiratory tract signs in 25% of cats diagnosed with asthma or bronchitis whereas another 13 reported nasal discharge more often in cats with chronic bronchitis than in those with asthma. An association of asthma with upper respiratory viruses has been noted in children, 37,38 and nasal airways in cats with experimentally induced asthma were noted to have eosinophilic infiltration in the absence of clinical signs 39 . Whether this finding was related to the method of hypersensitization via aerosolized allergen in the experimental study or represented a distinct response of the upper respiratory epithelium in those cats is unclear.…”

Section: Discussionmentioning

confidence: 98%

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

Lee

Johnson

et al. 2020

Veterinary Internal Medicne

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Background: Idiopathic inflammatory airway disease (IAD) in cats often is described as asthmatic (eosinophilic) or bronchitic (neutrophilic), but this designation requires collection of airway fluid and it fails to consider cats with mixed airway inflammation.Objective: To identify clinical features that would differentiate inflammatory disease types.Animals: Forty-nine cats with nonspecific airway inflammation identified by bronchoscopic bronchoalveolar lavage (BAL) between 2011 and 2018 were evaluated.Methods: This is a retrospective study. Cats were categorized by BAL differential cytology as having eosinophilic (eosinophils >20% with neutrophils <14%, or eosinophils >50%), mixed (eosinophils 20%-50% and neutrophils >14% or discordant inflammation from 2 BAL sites), or neutrophilic (neutrophils >14% and eosinophils <20%) inflammation. Type and duration of presenting complaints, signalment, body condition score, respiratory rate, CBC results, bronchoscopy, BAL results (% recovery, total nucleated cell count, differential cell count), and radiographic findings were compared among groups.Results: Idiopathic IAD was diagnosed in 49 cats, with BAL eosinophilic inflammation in 23, mixed inflammation in 14, and neutrophilic inflammation in 12. Cough was the predominant presenting complaint with no difference in duration of signs among groups (median, 5.5 months). Respiratory rate and effort also did not differ. Cats with eosinophilic inflammation were significantly younger (4.4 ± 3.3 years) than those with neutrophilic (8.0 ±5.6 years) or mixed inflammation (7.5 ± 4.0 years; P = .03). Results of CBC and interpretation of radiographic findings did not differ among groups.Conclusions and Clinical Importance: Substantial overlap exists in clinical and radiographic findings in cats with various forms of idiopathic airway inflammation.

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“…Recent work from clinical trials that were designed to prevent RSV infections, suggests that the development of asthma is confined to an at‐risk subgroup of children . In the largest study to date of healthy preterm infants, a link was found between severe RSV infection in infancy and current wheeze at 6 years of age, but only in those children without an atopic predisposition . In addition to infecting epithelial cells, RSV can infect both human CD4 + and CD8 + T cells, and the numbers of infected CD4 + T cells in the blood correlate with infection severity in children .…”

Section: T Cells In the Evolution Of Severe Asthmamentioning

confidence: 99%

T cells in severe childhood asthma

Paul

Muehling

Eccles

et al. 2019

Clin Experimental Allergy

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Summary Severe asthma in children is a debilitating condition that accounts for a disproportionately large health and economic burden of asthma. Reasons for the lack of a response to standard anti‐inflammatory therapies remain enigmatic. Work in the last decade has shed new light on the heterogeneous nature of asthma, and the varied immunopathologies of severe disease, which are leading to new treatment approaches for the individual patient. However, most studies to date that explored the immune landscape of the inflamed lower airways have focused on adults. T cells are pivotal to the inception and persistence of inflammatory processes in the diseased lungs, despite a contemporary shift in focus to immune events at the epithelial barrier. This article outlines current knowledge on the types of T cells and related cell types that are implicated in severe asthma. The potential for environmental exposures and other inflammatory cues to condition the immune environment of the lung in early life to favour pathogenic T cells and steroid resistance is discussed. The contributions of T cells and their cytokines to inflammatory processes and treatment resistance are also considered, with an emphasis on new observations in children that argue against conventional type 1 and type 2 T cell paradigms. Finally, the ability for new technologies to revolutionize our understanding of T cells in severe childhood asthma, and to guide future treatment strategies that could mitigate this disease, is highlighted.

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RSV hospitalization in infancy increases the risk of current wheeze at age 6 in late preterm born children without atopic predisposition

Cited by 19 publications

References 31 publications

Resolving the Debate on RSV Prophylaxis in Late Preterm Infants

Resolving the Debate on RSV Prophylaxis in Late Preterm Infants

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

T cells in severe childhood asthma

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