RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis

Amat, Flore; Plantard, Chloé; Mulliez, Aurélien; Petit, Isabelle; Rochette, Emmanuelle; Verdan, Matthieu; Henquell, Cécile; Labbé, G.; Heraud, M; Evrard, Bertrand; Labbé, A.

doi:10.1002/jmv.25037

Cited by 15 publications

(15 citation statements)

References 40 publications

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“…Our own results show a 4-fold increased risk of asthma in children with allergic sensitization. Therefore, although Amat et al, (27) did not nd association between viral coinfection and asthma at 3 years, the association of coinfections with allergic sensitization could be a predictor of asthma development in these coinfected children later in life.…”

Section: Discussionmentioning

confidence: 80%

“…Amat et al, (27), in a 3-year follow-up study of 154 children with a previous history of bronchiolitis (inpatient and outpatient), observed that 46.8% of them had been diagnosed with recurrent wheezing at age 3, identifying as risk factors only a family background of atopy and living in an apartment. In contrast, neither the type of virus identi ed, nor the single or multiple viral infections showed association with recurrent wheezing development.…”

Section: Discussionmentioning

confidence: 99%

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Role Of Viral Coinfections In Asthma Development In Children With Severe Bronchiolitis In Early Childhood

Ruiz¹,

Calvo²,

Pozo³

et al. 2020

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BACKGROUND. Severe viral bronchiolitis is associated with a higher risk of developing asthma, but little is known about the medium-term prognosis and the lung function evolution of patients admitted for viral coinfection-associated bronchiolitis. Our main objective was to compare the lung function, the prevalence of asthma and the rate of allergic sensitization at 6-9 years in children hospitalized for bronchiolitis with viral coinfection versus single viral infection.METHODS. Observational, longitudinal study in children previously hospitalized for viral bronchiolitis with current age between 6-9 years. Clinical and epidemiological data were collected. Fraction of exhaled nitric oxide determination, spirometry and skin prick test for common aeroallergens were performed.RESULTS. A total of 244 bronchiolitis-admitted children (52 coinfections and 192 single infections), with current age 6-9 years, accepted to participate by telephone answering the clinical questionnaires. Of them, 181 patients agreed for a medical visit. The overall frequency of asthma was 21%, being this prevalence almost twice as high in the viral coinfection group (p = 0.049). The coinfection cohort had more than twice as many admissions (p = 0.04), was more likely to receive montelukast (p = 0.06) and salmeterol/fluticasone treatment (p = 0.03) than the single-infection one. No differences regarding lung function values or allergic sensitization rate were observed between both groups.The variables independently related to current asthma at 6-9 years were: viral coinfection during bronchiolitis (p = 0.004), allergic rhinitis (p = 0.001), food allergy (p = 0.05) and atopic dermatitis (p = 0.017). CONCLUSIONS. Severe bronchiolitis associated with double or multiple viral detection in the first 24 months is an independent risk factor for higher frequency and greater severity of asthma at 6-9 years, being this risk almost three times higher compared to single infection. This fact is suggested by the higher frequency of current asthma, symptoms in intercrisis periods, maintenance anti-asthma treatment and number of hospitalizations for recurrent wheezing in children with coinfection compared to single infection. Early viral etiology identification in severe bronchiolitis might facilitate the prompt prediction and treatment of asthma in school age.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Role Of Viral Coinfections In Asthma Development In Children With Severe Bronchiolitis In Early Childhood

Ruiz¹,

Calvo²,

Pozo³

et al. 2020

Preprint

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“…Moreover, they confirmed the lack of association between RSV bronchiolitis and wheezing [ 46 ]. On the contrary, the study of Amat and colleagues [ 47 ] on a cohort of 154 hospitalized infants for bronchiolitis did not find any difference between the kind of respiratory virus (RSV in 76% of cases, RV in 28.6%, other viruses in 70.1% of cases) and the subsequent development of recurrent bronchial obstruction (intended as ≥3 respiratory symptoms documented in ≥2 times). However, the same study demonstrated that RV + RSV co-infected bronchiolitis was associated with the risk of sensitization to aeroallergens at three years at the multivariate analysis ( p = 0.02) [ 47 ].…”

Section: Long-term Sequelae Of Rv Bronchiolitismentioning

confidence: 91%

“…RV bronchiolitis has been found statistically associated with eosinophilia, especially with a blood eosinophil count >400/mm 3 [ 34 , 46 ], more frequently than non-RV bronchiolitis [ 19 , 28 , 30 ]. Moreover, as mentioned earlier, Amat and colleagues in 2018 found a correlation between co-infected RV + RSV bronchiolitis and the increased risk of sensitization to aeroallergens at three years at multivariate analysis [ 47 ]. The other peculiar RV-related immunological aspects are represented by the low IFN responses, especially IFN-γ.…”

Section: Long-term Sequelae Of Rv Bronchiolitismentioning

confidence: 97%

Rhinovirus Infection in Children with Acute Bronchiolitis and Its Impact on Recurrent Wheezing and Asthma Development

et al. 2020

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Acute bronchiolitis represents the leading cause of hospitalization in infants. Together with a respiratory syncytial virus, rhinovirus (RV) is one of the most common pathogens associated with bronchiolitis, and its genetic diversity (>150 types) makes the recurrence of RV infections each year quite typical. The frequency of RV infection and co-infection with other viruses and its impact on the clinical course of bronchiolitis have been studied by several authors with controversial results. Some studies demonstrate that multiple virus infections result in more severe clinical presentation and a higher risk of complications, whereas other studies suggest no influence on clinical course. Moreover, RV bronchiolitis has been reported to potentially contribute to the development of long-term sequelae, such as recurrent wheezing and asthma, in the pediatric population. In the present review, we summarize the most recent findings of the role of RV infection in children with acute bronchiolitis, its impact on subsequent asthma development, and the implication in clinical practice.

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“…Sólo el 28% de los niños presentan antecedentes familiares de bronquiolitis/bronquitis, estos datos no muestran que esta variable sea factor de riesgo y vemos la limitación en nuestro trabajo de no haber añadido a ella otros factores como atopia familiar, asma familiar, descritos en otros estudios como factores de riesgo (90)(91)(92).…”

Section: Discussionunclassified

Efectividad de una intervención educacional en la afectación de la bronquiolitis aguda en lactantes

Gómez¹

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AGRADECIMIENTOSLa parte más fácil de este Trabajo para mí, es sin duda, la de agradecer a muchas persones la ayuda incondicional que me han prestado para poder realizarlo. Llegar hasta aquí ha sido un privilegio, el premio a una trayectoria profesional y personal, al esfuerzo constante, a las horas robadas al sueño, pero sobre todo a mi familia que tan cariñosamente aceptaron y me apoyaron.Gracias a mi Directora de Tesis, la Dra. Pilar Isla, por su generosidad al brindarme su apoyo y conocimiento científico, por estar siempre cerca en los momentos de decaimiento, sin ella, no hubiera sido posible realizar esta investigación.Al Dr. Emiliano Mora por brindarme la oportunidad de recurrir a su capacidad y experiencia científica en un marco de confianza y amistad, fundamentales para mi y para la buena marcha de este Trabajo.A Roser Maeso y Carmen Rueda, enfermeras puericultoras y compañeras de carrera, de vida y de trabajo por su ayuda incondicional en la recogida de información durante los doce meses del proceso de recogida en el HU Mutua de Terrassa.A Mary y Charo, enfermeras puericultoras por su tiempo a la recogida de datos durante el proceso de realización de la Tesis en Áptima, Centre Clínic.A la Dra. Maite Valverde que con ella empezó todo, me animó a realizar el Máster y continuó siempre a mi lado hasta la presentación de esta tesis.Al Dr. Oscar Campuzano y Dra. Georgia Sarquella por su ayuda desinteresada sus consejos y cariño.A Conchi Caro Documentalista de HUMT por su apoyo incondicional en la búsqueda y ayuda en la corrección de la bibliografía.A mis compañeros de Trabajo, enfermeras y médicos, del Servicio de pediatría del HU Mutua de Terrassa, por el cariño demostrado, su paciencia y su apoyo.A Trini, enfermera y mi cuñada, por la confianza que tiene en mí.A Jordina Pujol, "mi becaria", alumna y compañera enfermera por colaborar en las llamadas telefónicas y a buscar datos utilizados durante el desarrollo del a Tesis.A mis hermanas Sofía, Nuria, Cecilia y hermanos Xavi y Jordi.A ti Roser la hermana rebelde a la que el cáncer le arrebató la vida, me gustaría que supieras que sí he llegado al máximo de mi carrera y que intentaré ser un ejemplo y guía para tu hija.A mis padres Bernardo y Charo, por infundir en mi la lucha y el deseo de superación. Desgraciadamente papá tu no estarás el día de la lectura de esta tesis, nos dejaste hace un tiempo ya pero quiero que sepas que te añoraré y echare a faltar esa sonrisa de satisfacción que tenías cuando alguien de los tuyos, de tus siete hijos, alcanzaba un éxito o simplemente era feliz.He dejado para el cierre de los agradecimientos a las persones que llenan de alegría el segundo a segundo de mi ser, a las persones que más quiero, a ellas porque sin ellas no tendría sentido mi vida ni mi amor, ni tampoco el esfuerzo en el trabajo: mi marido Joan por su apoyo en los momentos de duda, desesperación y felicidad, por su gran amor y por creer en mí; a mis hijas Andrea y Laura motor de mi existencia y de mi motivación; y a Ragga, ese perro que ha logrado conquistar mi ...

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RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis

Cited by 15 publications

References 40 publications

Role Of Viral Coinfections In Asthma Development In Children With Severe Bronchiolitis In Early Childhood

Role Of Viral Coinfections In Asthma Development In Children With Severe Bronchiolitis In Early Childhood

Rhinovirus Infection in Children with Acute Bronchiolitis and Its Impact on Recurrent Wheezing and Asthma Development

Efectividad de una intervención educacional en la afectación de la bronquiolitis aguda en lactantes

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