RTD analysis of a novel Taylor‐Couette flow device for blood detoxification

Grovender, Eric A.; Obradović, Bojana; Cooney, Charles L.; Langer, Robert

doi:10.1002/aic.690450320

Cited by 25 publications

(15 citation statements)

References 15 publications

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“…If the reactive chamber was 100% efficient, 50% of the plasma leaving the reactor would be cleared of heparin. However, mathematical modeling in our laboratory showed that for an enzyme loading of 20 ml of gel (16 units͞ml gel) the predicted conversion in the reactive chamber would be 92.6% for a transmembrane flow rate of 55 ml͞min (18). In addition, according to the model, 11% of the transmembrane flow bypasses the immobilized enzyme (49 ml͞min of the transmembrane plasma flow effectively encounters the immobilized heparinase).…”

Section: Resultsmentioning

confidence: 96%

Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application

Ameer

Barabino

Sasisekharan

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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Efficient and safe heparin anticoagulation has remained a problem for continuous renal replacement therapies and intermittent hemodialysis for patients with acute renal failure. To make heparin therapy safer for the patient with acute renal failure at high risk of bleeding, we have proposed regional heparinization of the circuit via an immobilized heparinase I filter. This study tested a device based on Taylor-Couette f low and simultaneous separation͞ reaction for efficacy and safety of heparin removal in a sheep model. Heparinase I was immobilized onto agarose beads via cyanogen bromide activation. The device, referred to as a vortex f low plasmapheretic reactor, consisted of two concentric cylinders, a priming volume of 45 ml, a microporous membrane for plasma separation, and an outer compartment where the immobilized heparinase I was f luidized separately from the blood cells. Manual white cell and platelet counts, hematocrit, total protein, and fibrinogen assays were performed. Heparin levels were indirectly measured via wholeblood recalcification times (WBRTs). The vortex f low plasmapheretic reactor maintained significantly higher heparin levels in the extracorporeal circuit than in the sheep (device inlet WBRTs were 1.5 times the device outlet WBRTs) with no hemolysis. The reactor treatment did not effect any physiologically significant changes in complete blood cell counts, platelets, and protein levels for up to 2 hr of operation. Furthermore, gross necropsy and histopathology did not show any significant abnormalities in the kidney, liver, heart, brain, and spleen.

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Section: Resultsmentioning

confidence: 96%

Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application

Ameer

Barabino

Sasisekharan

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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“…For Re < 40 the vortices are torroidal, while for Re > 40 the vortices are in the form a helix. The combination of the Couette flow and Taylor instabilities, referred to as Couette-Taylor (CT) flow, results in intense local mixing with limited axial dispersion, making CT flow devices suitable for a wide range of applications, including: blood detoxification [6], precipitation [7], reverse osmosis [8], polymerization [9], photocatalysis [10], extraction [11,12], and processes involving gas-liquid flows [1,2].…”

Section: Introductionmentioning

confidence: 99%

Horizontal Couette–Taylor flow in a two-phase gas–liquid system: flow patterns

Hubacz

Wroński

2004

Experimental Thermal and Fluid Science

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“…The most of the shear-enhanced filtration techniques have been shown to be efficient in improving MF and UF processes in terms of permeate flux increasing. The dynamic filtration systems were successfully implement in different fields of research and engineering such as chemical and environmental engineering including water, wastewater and radioactive liquid waste treatment [4,[7][8][9]11,[18][19][20][21][22]; biotechnological separations [4,6,10,12,13,[15][16][17]26]; as well as medical engineering [4,27].…”

Section: Introductionmentioning

confidence: 99%