rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression

Zhao, Lin; Ren, Hanyun; Gu, Song; Li, Xiaodan; Jiang, Chunxiang; Li, Juan; Zhang, Mengmeng; Mu, Junlin; Li, Wenqiang; Wang, Wensheng; Zhao-hui, Zhang; Song, Jinggui

doi:10.1016/j.psychres.2018.08.017

Cited by 43 publications

(34 citation statements)

References 33 publications

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“…Depression, a major burden around the world, brings serious disability, now ranking in second place with respect to adjusted life years of disability among all age groups (Planchez et al, 2019). Previous studies have shown obvious damage and hippocampal neuron loss in depression model rat hippocampus (Bakhtiarzadeh et al, 2018;Zhao L. et al, 2018). The results we obtained also showed consistent changes, whereas the GP treatment could alleviate CUMS-induced depression-like behavior and hippocampal damage in mice.…”

Section: Discussionsupporting

confidence: 74%

“…However, knockdown of Six3os1 reduced the SOD, GSH, and CAT contents and elevated MDA content in CUMS-induced mice with GP treatment, which was negated by upregulating Fezf1. In other studies, GP treatment alleviated depression-like behavior caused by repeated restraint stress through suppression of neuronal apoptosis via the modulation of the GLP-1R/AKT signaling pathway (Zhao L. et al, 2018). Moreover, GP can correct depression-like behavior of offspring from prenatally stressed mice by repressing DNA methyltransferase 1, i.e., an epigenetic mechanism (Zhao L. et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

“…These mice were randomly housed in cages with a 12-h dark-light cycle, with lights on at 7:00 a.m., 60% humidity, air temperature of 24 • C, and free access to water and food. All mice were acclimated for 1 week before CUMS treatment (Zhao L. et al, 2018;Guo et al, 2019). The 15 mice underwent control-operation were intragastrically administrated with DMSO.…”

Section: Establishment Of a Cums Mouse Model With Depression-like Behmentioning

confidence: 99%

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Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1

Zou

Sugimoto

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Depression is a major cause of disease burden and severely impairs well-being of patients around the globe. Geniposide (GP) has been revealed to play a significant role in depression treatment. Of note, RNA sequencing of this study identified highly expressed long non-coding RNA Six3os1 in response to GP treatment. Thus, we aim to explore how GP affected chronic unpredictable mild stress (CUMS)-induced depressionlike behaviors in mice in vivo and in vitro and the downstream molecular mechanism related to Six3os1. The relationship of Six3os1, miR-511-3p and Fezf1 was evaluated by dual-luciferase reporter gene assay, RIP assay, and RNA pulling down assay. Ectopic expression and knockdown experiments were developed in CUMS-induced mice and neurons with or without GP treatment. In vitro experiments and behavioral tests were conducted to examine alteration of CUMS-triggered oxidative stress following different interferences. The experimental data validated that GP treatment resulted in high expression of Six3os1 and Fezf1 and poor expression of miR-511-3p in CUMS-induced neurons. Six3os1 activated the AKT signaling pathway by upregulating miR-511-3ptargeted Fezf1. Either GP treatment or overexpression of Six3os1 or Fezf1 alleviated depression-like behaviors of CUMS-induced mice. GP treatment, miR-511-3p inhibition or overexpression of Six3os1 or Fezf1 not only reduced oxidative stress in CUMSinduced mice and neurons, but also reduced CUMS-induced neuronal apoptosis. Collectively, GP treatment-mediated Six3os1 upregulation ameliorated oxidative stress of mice with depression-like behaviors via the miR-511-3p/Fezf1/AKT axis.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 98%

Section: Establishment Of a Cums Mouse Model With Depression-like Behmentioning

confidence: 99%

See 1 more Smart Citation

Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1

Zou

Sugimoto

Zhang

et al. 2020

Front. Cell Dev. Biol.

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“…Moreover, several preclinical studies have observed that rTMS increased the content of BDNF in the hippocampus and PFC, and promoted hippocampal neurogenesis in rodent CUMS, CUS, and olfactory bulbectomy depression models[ 44 , 46 - 49 ]. However, there are inconsistencies between the results of preclinical and clinical studies.…”

Section: Activation Of Endocannabinoid System and Brain Derived Neuromentioning

confidence: 99%

“…As a result, it has not been possible to use HPA related measurements in the diagnosis of MDD, and there may be many mechanisms that have not been clarified. rTMS at 10 Hz (intensity, 50 % of the resting motor threshold) and 15 Hz (intensity, device maximum power) reduced the levels of adrenocorticotropic hormone and cortisol in peripheral blood of depressive-like rats induced by CUMS[ 46 , 49 ]. There are few preclinical and clinical studies supporting that rTMS exerts an anti-depressant effect by reducing the activity of the HPA axis, and the current evidence is still insufficient.…”

Section: Decreasing the Activity Of The Hypothalamic-pituitary-adrenomentioning

confidence: 99%

Mechanisms of repetitive transcranial magnetic stimulation for anti-depression: Evidence from preclinical studies

Luan

Zhao

Shi

et al. 2020

WJP

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This review summarizes the anti-depressant mechanisms of repetitive transcranial magnetic stimulation in preclinical studies, including anti-inflammatory effects mediated by activation of nuclear factor-E2-related factor 2 signaling pathway, anti-oxidative stress effects, enhancement of synaptic plasticity and neurogenesis via activation of the endocannabinoid system and brain derived neurotrophic factor signaling pathway, increasing the content of monoamine neurotransmitters via inhibition of Sirtuin 1/monoamine oxidase A signaling pathway, and reducing the activity of the hypothalamic-pituitary-adrenocortical axis. We also discuss the shortcomings of transcranial magnetic stimulation in preclinical studies such as inaccurate positioning, shallow depth of stimulation, and difficulty in elucidating the neural circuit mechanism up- and down-stream of the stimulation target brain region.

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Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

Zeng

Tian

et al. 2020

Anim Models and Exp Med

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Background:The chronic unpredictable mild stress (CUMS) model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression. However, there are no widely recognised standards for strategies for modeling and for behavioral testing. The present study aimed to optimize the protocols for food deprivation and the sucrose preference test (SPT) for the CUMS model. Methods:We first evaluated the effects of different long periods of food deprivation on the body weight of Sprague Dawley (SD) rats by testing food deprivation for 24 hours (8:00-8:00 + ), food deprivation for 12 hours during the daytime (8:00-20:00) and food deprivation for 12 hours at night (20:00-8:00 + ). Next, we established a SD rat CUMS model with 15 different stimulations, and used body weight measurement, SPT, forced swim test (FST), open field test (OFT) and Morris water maze (MWM) test to verify the success of the modeling. In the SPT, consumption of sucrose and pure water within 1 and 12 hours was measured.Results: Twelve hours of food deprivation during the daytime (8:00-20:00) had no effect on body weight, while 12 hours of food deprivation at night (20:00-8:00 + ) and 24 hours of food deprivation (8:00-8:00 + ) significantly reduced the mean body weight of the SD rats. When SPT was used to verify the successful establishment of the CUMS rat model, sucrose consumption measured within 12 hours was less variable than that measured within 1 hour. Conclusions:Twelve hours of food deprivation in the daytime (8:00-20:00) may be considered a mild stimulus for the establishment of a CUMS rat model. Measuring sucrose consumption over 12 hours is recommended for SPT. K E Y W O R D S chronic unpredictable mild stress, forced swim test, Morris water maze, open field test, sucrose preference test, weight body

show abstract

rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression

Cited by 43 publications

References 33 publications

Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1

Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1

Mechanisms of repetitive transcranial magnetic stimulation for anti-depression: Evidence from preclinical studies

Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

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