rTMS/iTBS and Cognitive Rehabilitation for Deficits Associated With TBI and PTSD: A Theoretical Framework and Review

Lindsey, André; Ellison, Rachael L.; Herrold, Amy A.; Aaronson, Alexandra; Kletzel, Sandra; Stika, Monica; Guernon, Ann; Pape, Theresa

doi:10.1176/appi.neuropsych.21090227

Cited by 9 publications

(3 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…59 There is growing evidence that iTBS may be a promising intervention for targeting the cognitive control network in individuals with a variety of neuropsychiatric disorders, such as traumatic brain injury, posttraumatic stress disorder, and poststroke cognitive impairment. [60][61][62] In addition, a recent study found that iTBS improved cognitive control and working memory performance in healthy adults. 63 While further research is needed, preliminary evidence suggests that iTBS could be a promising intervention for treating dysfunction in the cognitive control network.…”

Section: Discussionmentioning

confidence: 99%

“…These deficits have a significant impact on a range of cognitive and behavioral processes involved in attentional control, working memory, and executive functions and are associated with impaired daily functioning 59 . There is growing evidence that iTBS may be a promising intervention for targeting the cognitive control network in individuals with a variety of neuropsychiatric disorders, such as traumatic brain injury, posttraumatic stress disorder, and poststroke cognitive impairment 60–62 . In addition, a recent study found that iTBS improved cognitive control and working memory performance in healthy adults 63 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Therapeutic Role of Intermittent Theta Burst Stimulation in Schizophrenia

Salabat,

Pourebrahimi,

Mayeli

et al. 2024

J ECT

View full text Add to dashboard Cite

Schizophrenia affects approximately 1% of the population worldwide. Multifactorial reasons, ranging from drug resistance to adverse effects of medications, have necessitated exploring further therapeutic options. Intermittent theta burst stimulation (iTBS) is a novel high-frequency form of transcranial magnetic stimulation, a safe procedure with minor adverse effects with faster and longer-lasting poststimulation effects with a potential role in treating symptoms; however, the exact target brain regions and symptoms are still controversial. Therefore, we aimed to systematically investigate the current literature regarding the therapeutic utilities of iTBS using Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Twelve studies were included among which 9 found iTBS effective to some degree. These studies targeted the dorsolateral prefrontal cortex and the midline cerebellum. We performed a random-effects meta-analysis on studies that compared the effects of iTBS on schizophrenia symptoms measured by the Positive and Negative Syndrome Scale (PANSS) to sham treatment. Our results showed no significant difference between iTBS and sham in PANSS positive and negative scores, but a trend-level difference in PANSS general scores (k = 6, P = 0.07), and a significant difference in PANSS total scores (k = 6, P = 0.03). Analysis of the studies targeting the dorsolateral prefrontal cortex showed improvement in PANSS negative scores (k = 5, standardized mean difference = −0.83, P = 0.049), but not in PANSS positive scores. Moderators (intensity, pulse, quality, sessions) did not affect the results. However, considering the small number of studies included in this meta-analysis, future works are required to further explore the effects of these factors and also find optimum target regions for positive symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Therapeutic Role of Intermittent Theta Burst Stimulation in Schizophrenia

Salabat,

Pourebrahimi,

Mayeli

et al. 2024

J ECT

View full text Add to dashboard Cite

show abstract

“…rTMS. A decade of theoretical pieces [102][103][104][105] and review papers [103,[106][107][108][109][110] enthuse the potential of rTMS to treat the long-term cognitive and psychiatric consequences of TBI with a more tempered set of outcomes. rTMS applies alternating magnetic fields generated from a coil placed on the scalp to non-invasively induce a neural response with minimal side effects [111].…”

Section: Rtms and Tdcs Benefits In Rodents After Tbimentioning

confidence: 99%

The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies

McNerney,

Gurkoff,

Beard

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Neurostimulation carries high therapeutic potential, accompanied by an excellent safety profile. In this review, we argue that an arena in which these tools could provide breakthrough benefits is traumatic brain injury (TBI). TBI is a major health problem worldwide, with the majority of cases identified as mild TBI (mTBI). MTBI is of concern because it is a modifiable risk factor for dementia. A major challenge in studying mTBI is its inherent heterogeneity across a large feature space (e.g., etiology, age of injury, sex, treatment, initial health status, etc.). Parallel lines of research in human and rodent mTBI can be collated to take advantage of the full suite of neuroscience tools, from neuroimaging (electroencephalography: EEG; functional magnetic resonance imaging: fMRI; diffusion tensor imaging: DTI) to biochemical assays. Despite these attractive components and the need for effective treatments, there are at least two major challenges to implementation. First, there is insufficient understanding of how neurostimulation alters neural mechanisms. Second, there is insufficient understanding of how mTBI alters neural function. The goal of this review is to assemble interrelated but disparate areas of research to identify important gaps in knowledge impeding the implementation of neurostimulation.

show abstract