rTMS zur Behandlung von Schlafstörungen - zwei Kasuistiken

Kunze, Tamara; Langguth, Berthold; Eichhammer, Peter; Hajak, Göran; Fleischmann, Heribert

doi:10.1055/s-2006-940186

Cited by 3 publications

(4 citation statements)

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“…Low‐frequency (1 Hz) rTMS over the right dorsolateral prefrontal cortex (DLPFC) is relatively common at present. It was first used by Kunze, Langguth, Eichhammer, Hajak, and Fleischmann () and found to significantly increase the total sleep duration of insomnia patients. Recently, neuroimaging has also suggested that insomnia patients have higher excitability in the bilateral dorsolateral prefrontal cortex (DLPFC) compared with healthy individuals (Nofzinger, ).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of sequential bilateral low‐frequency rTMS over dorsolateral prefrontal cortex on serum level of BDNF and GABA in patients with primary insomnia

Feng

Zhang

et al. 2019

Brain and Behavior

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Objective This study aimed to investigate the effect of sequential bilateral low‐frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex (DLPFC) on patients with primary insomnia (PI). Methods A total of 32 eligible right‐handed participants diagnosed by PI according to International classification of sleep disorders (ICD‐3) were recruited into this study. Participants received 10 daily sessions of sequential bilateral 1 Hz rTMS over DLPFC. Before and after the whole procedure of rTMS, patients were assessed by Pittsburgh Sleep Quality Index (PSQI) for the severity of sleep disturbance. Meanwhile, serum concentration of brain‐derived neurotrophic factor (BDNF) and gamma‐aminobutyric acid (GABA) in patients was measured by ELISA and UPLC, respectively. Moreover, the amplitude of MEPs reflecting the right cortical excitability was examined. Finally, Pearson correlation analysis was performed to evaluate the correlation among the change of these variables. Results After rTMS treatment, the PSQI score was markedly decreased as compared to pre‐rTMS; the concentrations of serum BDNF and GABA were significantly higher; the amplitude of MEPs was markedly reduced. Pearson correlation analysis revealed that the change of PSQI score was negatively associated with the alteration of serum BDNF level and serum GABA level, and positively associated with the change of MEPs amplitude; the change of MEPs amplitude was negatively associated with fold change in the serum BDNF level and the serum GABA level; the increase in serum GABA level was positively associated with the serum BDNF level. Conclusions A sequential bilateral low‐frequency rTMS over DLPFC significantly improves primary insomnia probably by increasing the level of BDNF and GABA in the brain and reducing cortical excitability.

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Section: Introductionmentioning

confidence: 99%

“…Low-frequency (1 Hz) rTMS over the right dorsolateral prefrontal cortex (DLPFC) is relatively common at present. It was first used by Kunze, Langguth, Eichhammer, Hajak, and Fleischmann (2007) and…”

Section: Introductionmentioning

confidence: 99%

The Effect of sequential bilateral low‐frequency rTMS over dorsolateral prefrontal cortex on serum level of BDNF and GABA in patients with primary insomnia

Feng

Zhang

et al. 2019

Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…Although the sample size for each condition group in this study was very small, these results can be used as preliminary evidence that tDCS treatments could help insomnia patients fall asleep faster, after further research. Similarly, Kunze et al (2007) in two case reports briefly describe how using rTMS reduced sleep onset latency for 2 individuals with insomnia. rTMS was delivered across 15 sessions on the dorsolateral prefrontal cortex, with one participant receiving 1 Hz stimulation on the right DLPFC, and the other receiving 10 Hz rTMS on the left DLPFC ( Kunze et al, 2007 ).…”

Section: Translational Approaches To Influence Different Aspects Of S...mentioning

confidence: 99%

“…Similarly, Kunze et al (2007) in two case reports briefly describe how using rTMS reduced sleep onset latency for 2 individuals with insomnia. rTMS was delivered across 15 sessions on the dorsolateral prefrontal cortex, with one participant receiving 1 Hz stimulation on the right DLPFC, and the other receiving 10 Hz rTMS on the left DLPFC ( Kunze et al, 2007 ). Once again, little information is available and the sample size of this study was very small, but these preliminary findings suggest that rTMS might help people with insomnia fall asleep faster.…”

Section: Translational Approaches To Influence Different Aspects Of S...mentioning

confidence: 99%