RTOG quality assurance guidelines for interstitial hyperthermia

Emami, Bahman; Stauffer, Paul R.; Dewhirst, Mark W.; Prionas, Stavros D.; Ryan, Thomas P.; Corry, Peter M.; Herman, TS; Kapp, Daniel S.; Myerson, Robert J.; Samulski, Thaddeus V.; Sapareto, Stephen A.; Sapozink, Michael D.; Shrivastava, Prakash N.; Waterman, Frank M.

doi:10.1016/0360-3016(91)90213-n

Cited by 59 publications

(16 citation statements)

References 33 publications

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“…These were based largely on the idea of using multi-sensor probes or single sensor probes that can be moved inside a pre-placed catheter that is placed inside a tumour during treatment [47]. Guidelines for acquisition of multi-point thermometry data were published several years ago [48][49][50][51][52][53] and are in the process of being updated, under sponsorship of the thermal therapy societies in the US and Europe.…”

Section: Redefining Thermal Goals For Hyperthermia Treatmentmentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

283

199

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This review takes a retrospective look at how hyperthermia biology, as defined from studies emerging from the late 1970s and into the 1980s, mis-directed the clinical field of hyperthermia, by placing too much emphasis on the necessity of killing cells with hyperthermia in order to define success. The requirement that cell killing be achieved led to sub-optimal hyperthermia fractionation goals for combinations with radiotherapy, inappropriate sequencing between radiation and hyperthermia and goals for hyperthermia equipment performance that were neither achievable nor necessary. The review then considers the importance of the biologic effects of hyperthermia that occur in the temperature range that lies between that necessary to kill substantial proportions of cells and normothermia (e.g. 39-42 degrees C for 1 h). The effects that occur in this temperature range are compelling-including inhibition of radiation-induced damage repair, changes in perfusion, re-oxygenation, effects on macromolecular and nanoparticle delivery, induction of the heat shock response and immunological stimulation, all of which can be exploited to improve tumour response to radiation and chemotherapy. This new knowledge about the biology of hyperthermia compels one to continue to move the field forward, but with thermal goals that are eminently achievable and tolerable by patients. The fact that lower temperatures are incorporated into thermal goals does not lessen the need for non-invasive thermometry or more sophisticated hyperthermia delivery systems, however. If anything, it further compels one to move the field forward on an integrated biological, engineering and clinical level.

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Section: Redefining Thermal Goals For Hyperthermia Treatmentmentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

283

199

View full text Add to dashboard Cite

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“…In three follow-up papers the RTOG published guidelines to address quality assurance issues pertaining to deep tissue. (115) RTOG quality assurance guidelines for interstitial hyperthermia (116) and ultrasound. (117) Recently, leading experts in the United States published a review of the competencies and tasks used in a hyperthermia clinic.…”

Section: Challenges To Clinical Implementationmentioning

confidence: 99%

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hurwitz

Stauffer

2014

Seminars in Oncology

123

104

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“…Interstitial hyperthermia (IHT) treatment is scheduled before every brachytherapy fraction and it should end no more than one hour before the start of irradiation. Hyperthermia will be carried out in accordance with the QA guidelines published by the RTOG for interstitial hyperthermia [ 21 ]. Catheters implanted to the prostate during the implantation procedure will be used to place microwave antennas and temperature probes.…”

Section: Hyperthermiamentioning

confidence: 99%

Educational article Salvage brachytherapy in combination with interstitial hyperthermia for locally recurrent prostate carcinoma following external beam radiation therapy: a prospective phase II study

Kukielka¹,

Strnad²,

Stauffer³

et al. 2015

jcb

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Optimal treatment for patients with only local prostate cancer recurrence after external beam radiation therapy (EBRT) failure remains unclear. Possible curative treatments are radical prostatectomy, cryosurgery, and brachytherapy. Several single institution series proved that high-dose-rate brachytherapy (HDRBT) and pulsed-dose-rate brachytherapy (PDRBT) are reasonable options for this group of patients with acceptable levels of genitourinary and gastrointestinal toxicity. A standard dose prescription and scheme have not been established yet, and the literature presents a wide range of fractionation protocols. Furthermore, hyperthermia has shown the potential to enhance the efficacy of re-irradiation.Consequently, a prospective trial is urgently needed to attain clear structured prospective data regarding the efficacy of salvage brachytherapy with adjuvant hyperthermia for locally recurrent prostate cancer. The purpose of this report is to introduce a new prospective phase II trial that would meet this need. The primary aim of this prospective phase II study combining Iridium-192 brachytherapy with interstitial hyperthermia (IHT) is to analyze toxicity of the combined treatment; a secondary aim is to define the efficacy (bNED, DFS, OS) of salvage brachytherapy. The dose prescribed to PTV will be 30 Gy in 3 fractions for HDRBT, and 60 Gy in 2 fractions for PDRBT. During IHT, the prostate will be heated to the range of 40–47°C for 60 minutes prior to brachytherapy dose delivery. The protocol plans for treatment of 77 patients.

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RTOG quality assurance guidelines for interstitial hyperthermia

Cited by 59 publications

References 33 publications

Re-setting the biologic rationale for thermal therapy

Re-setting the biologic rationale for thermal therapy

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Educational article Salvage brachytherapy in combination with interstitial hyperthermia for locally recurrent prostate carcinoma following external beam radiation therapy: a prospective phase II study

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