Ru(II)‐Catalyzed C−H Alkylation of N‐Benzyltriflamide with Maleimides: Synthesis of o‐Succinimide Substituted Benzaldehydes

Abstract

A ruthenium‐catalyzed N‐benzyltriflamide assisted C‐H alkylation with maleimide followed by hydrolysis of in situ generated imine has been developed for the first time. This synthetic method results in the efficient synthesis of o‐succinimide derivatives of benzaldehydes. This reaction involves less expensive and mild reaction conditions and shows excellent site selectivity and good functional group compatibility.

Ru(II)-Catalyzed C–H Activation/[4+2] Annulation of Sulfoxonium Ylide with Maleimide: Access to Fused Benzo[e]isoindole-1,3,5-trione

“…This is attributed to their greener and economically efficient approaches for obtaining functionalized molecules. , Regioselective C–H functionalization using a directing group-assisted strategy demonstrates high potential and significant achievement in developing novel reactions and their mechanistic studies . In the past decade, various directing groups have been employed in metal-catalyzed C–H functionalization . In this context, using sulfoxonium ylide metal carbenes in C–H activation introduces new avenues for exploration.…”