Ru(II) polypyridine complexes with a high oxidation power. Comparison between their photoelectrochemistry with transparent SnO2 and their photochemistry with desoxyribonucleic acids

Ortmans, Isabelle; Moucheron, Cécile; Mesmaeker, Andrée Kirsch‐De

doi:10.1016/s0010-8545(97)00070-2

Cited by 103 publications

(51 citation statements)

References 112 publications

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“…[8] Ruthenium polypyridine complexes are undoubtedly the main class of molecules which may bind to DNA through intercalation, inducing cleavage of the DNA backbone through photoxidation. [9] The sequence specificity of these complexes has been investigated with known sequence oligonucleotides, mainly by means of NMR techniques, but no general rules about such selectivity have been suggested.…”

Section: (Phenј)]mentioning

confidence: 99%

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)₂(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl₂−¹H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)₂]

2004

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The synthesis and characterization of the diastereomeric complexes Λ-and ∆-[Ru(bpy) 2 (m-bpy-GHK)]Cl 2 , (GHK = glycine-L-histidine-L-lysine, m-bpy = 4͉-methyl-2,2͉-bipyridine) as well as their binding properties to the deoxynucleotide duplex d(5Ј-CGCGAATTCGCG-3Ј) 2 studied by means of NMR, ESI-MS and CD spectroscopy, are reported. The ROESY spectrum of Λ-[Ru(bpy) 2 (m-bpy-GHK)]Cl 2 shows intramolecular cross peaks between the bpy H3 or H3Ј protons and the aromatic H2 and H5 of the histidine imidazole ring, indicating that the peptide adopts an orientation with the imidazole ring close to the bpy ligand, possibly interacting by π-stacking. The absence of intramolecular cross peaks between the peptide and the bipyridine ligands in the ROESY

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Section: (Phenј)]mentioning

confidence: 99%

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)₂(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl₂−¹H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)₂]

2004

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“…In this context, the interaction and photoreaction of Ru II complexes with DNA have been the subject of intensive studies. [3][4][5][6][7][8][9][10][11] Some of these compounds turned out to be particularly attractive. In fact, they are able to produce, upon illumination, addition of the metal-containing complex to the guanine units of DNA, which inhibits certain enzymes such as RNA polymerase.…”

Section: Introductionmentioning

confidence: 99%

Photoreaction of [Ru(hat)₂phen]²⁺ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts

Blasius

Nierengarten²,

Luhmer

et al. 2005

Chemistry A European J

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[Ru(hat)2phen]2+ (HAT=1,4,5,8,9,12-hexaazatriphenylene, phen=1,10-phenanthroline) interacts with a good affinity with polynucleotides and DNA by intercalation, despite the presence of a second voluminous ancillary HAT ligand. It photoreacts with guanosine-5'-monophosphate (GMP). From HPLC, ESMS and NMR analyses, it can be concluded that this complex forms photoadducts with GMP. In contrast to the photoadducts isolated with Ru-TAP complexes (TAP=1,4,5,8-tetraazaphenanthrene), the photoadducts with [Ru(hat)2phen]2+ contain a covalent link between the oxygen atom of the guanine unit and a HAT ligand. Formation of oxidised photoadducts and compounds resulting from the addition of two GMP entities to the complex are also detected as side products. In the presence of oligo- and polynucleotides, [Ru(hat)2phen]2+ yields photoadducts when guanine bases are present.

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“…88 In special cases, the photoelectrochemistry data quite convincingly demonstrated a reduced sensitizer injection mechanism. 128 The observation of ultrafast electron injection coupled with the weak oxidizing power of the excited sensitizers currently in use strongly suggests that an excited-state injection mechanism is operative in regenerative solar cells based on these materials. Nevertheless, absolute proof is lacking as ultrafast spectroscopic studies are rarely done on the fully assembled dye-sensitized solar cell.…”

Section: Reduced Sensitizer Interfacial Charge Separationmentioning

confidence: 99%

Solar Photochemistry with Transition Metal Compounds Anchored to Semiconductor Surfaces

Meyer

2010

Physical Inorganic Chemistry

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There exists a critical need for sustainable power on a terawatt (TW ¼ 10 12 W) scale. 1,2 As the world's need for energy is related to the number of people on Earth, a staggering 45% population growth over the last quarter-century equates to roughly 2 billion people and a 6 TW ($63%) increase in needed power. 3 In addition, the urbanism of third-world and industrialized nations and cities has led to an increase in the demand for fuel that has driven gas and oil prices to record highs. 3 Regardless of price, the continued use of fossil fuels cannot be a long-term solution as they come from a limited stock and the deleterious environmental consequences of their combustion have become self-evident. 4,5 The increased average global temperature and rates of glacial melting measured over the past few decades are telling signs. [6][7][8][9] Concern should be elicited as ice-core data correlate temperature with greenhouse gas concentrations over the past half-a-million years. The present 380 ppm atmospheric CO 2 levels exceed any values attained over the same time period. 5,6 Further, other than natural photosynthesis, there exist no obvious means by which we can decrease today's level. Thus, population, energy demand, and fuel prices do not convey the severity of the need for sustainable energy.It is our belief that molecular assemblies, particularly molecules arranged at semiconductor interfaces, will one day efficiently harvest and convert energy from the Sun, thereby providing sustainable, carbon-neutral power for future generations. The Sun is in fact the only source that on its own can provide the TWs of power needed. It has been shown that the amount of solar energy reaching the Earth in one day could power the planet for an entire year. 7,8 Remaining is the important challenge of harvesting, converting, and storing this energy in a cost-effective way. Coordination Physical Inorganic Chemistry: Reactions, Processes, and Applications Edited by Andreja Bakac

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Ru(II) polypyridine complexes with a high oxidation power. Comparison between their photoelectrochemistry with transparent SnO2 and their photochemistry with desoxyribonucleic acids

Cited by 103 publications

References 112 publications

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)₂(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl₂−¹H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)₂]

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)₂(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl₂−¹H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)₂]

Photoreaction of [Ru(hat)₂phen]²⁺ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts

Solar Photochemistry with Transition Metal Compounds Anchored to Semiconductor Surfaces

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Ru(II) polypyridine complexes with a high oxidation power. Comparison between their photoelectrochemistry with transparent SnO2 and their photochemistry with desoxyribonucleic acids

Cited by 103 publications

References 112 publications

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)2(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl2−1H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)2]

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)2(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl2−1H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)2]

Photoreaction of [Ru(hat)2phen]2+ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts

Solar Photochemistry with Transition Metal Compounds Anchored to Semiconductor Surfaces

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Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)₂(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl₂−¹H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)₂]

Synthesis and Characterization of the Diastereomers Λ‐ and Δ‐[Ru(bpy)₂(m‐bpy‐Gly‐L‐His‐L‐Lys)]Cl₂−¹H NMR Studies on Their Interactions with the Deoxynucleotide Duplex d[(5′‐CGCGAATTCGCG‐3′)₂]

Photoreaction of [Ru(hat)₂phen]²⁺ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts