Ru^II–Carbonyl photoCORMs with N,N‐Benzimidazole Bidentate Ligands: Spectroscopic, Lysozyme Binding Affinity, and Biological Activity Evaluation

Abstract

The photoinduced carbon monoxide releasing properties of pyridylbenzimidazole-based Ru II -carbonyl complexes functionalized with alkylated sulfonate (L SO3H ), phthalimide (L Phth ), and morpholine (L morph ) moieties, [RuCl(CO) 3 L SO3H ]Cl (1) and [RuCl 2 (CO) 2 L] {where L = L Phth (2) and L morph (3)}, are reported. The geometrical stereochemistry and electronic transitions are assigned with the aid of DFT and TDDFT calculations. The compounds are evaluated for potential antimicrobial and [a]

Dinuclear copper(II) complex with a benzimidazole derivative: Crystal structure, theoretical calculations, and cytotoxic activity

“…Moreover, under the same experimental conditions, the commercially available drugs cisplatin (IC 50 = 1.1 ± 0.2 μ m ) and carboplatin (IC 50 = 10 ± 1 μ m ) exhibit cytotoxic activity in the same order of magnitude as the newly synthesized compound . Similarly, previous studies of copper‐based complexes containing benzimidazole derivatives have demonstrated that the antineoplastic potential of benzimidazoles enhance upon copper(II) coordination …”

“…[55] Similarly, previous studies of copper-based complexes containing benzimidazole derivatives have demonstrated that the antineoplastic potential of benzimidazoles enhance upon copper(II) coordination. [3,[5][6][7]10] Furthermore, as the ligand dppb presents certain planarity because the pyridine and the benzimidazole ring systems are almost coplanar, [49] it is interesting to investigate the interactions of its copper complex with DNA. For most copper(II) complexes, which act as antiproliferative agents, DNA binding is a crucial step for DNA cleavage and fragmentation.…”

“…Metal complexes bearing benzimidazole derivatives with considerable structural diversity, including mononuclear and multinuclear compounds, have been recently reported by many groups while some ring‐like coordination compounds have also been reported . This assortment of metal–organic structures is favored by the versatile coordination modes of benzimidazole‐type ligands.…”

Spectroscopic and DFT studies of photoactivatable Mn(I) tricarbonyl complexes

“…2‐(2′‐pyridyl)benzimidazole ligands functionalized with morpholine (L morph ) and phthalimideo (L phth ) were synthesized following the published procedures . Manganese pentacarbonyl bromide was received from Strem chemicals.…”

“…The functionalized morpholine (L morph ) and phthalimide (L phth ) ligands based on 2-(2′-pyridyl) benzimidazole were synthesized following the previously published method. [32] Heating to reflux the 1:1 (M: L) reaction mixture of manganese(I) pentacarbonyl bromide and the corresponding ligand yielded fac-[MnBr (CO) 3 L] (L = L morph (1) and L phth (2)) (Scheme 1). The complexes were characterized by elemental analysis, ESI-MS, IR and NMR ( 1 H, 13 C NMR, { 1 H, 1 H} COS90, and { 1 H, 13 C} HSQC) ( Figure S1-3).…”