Ru^III Complexes of Edta and Dtpa Polyaminocarboxylate Analogues and Their Use as Nitric Oxide Scavengers

Abstract

In this study a series of Ru III complexes, chelated by analogues of ethylenediaminetetraacetic acid (edta) and diethylenetriaminepentaacetic acid (dtpa), were produced and tested for NO scavenging ability. Modifications to the edta and dtpa ligand frameworks were made in an effort to alter the reactivity, aqueous stability and pharmacokinetics of the resulting Ru III complexes. The X-ray structure of the nitrosyl complex 38 confirms that the Ru III complex 27 reacts with NO to form a linear {Ru-NO} [6] complex. The nitrosyl complex [C 15

Application of aziridinium ring opening for preparation of optically active diamine and triamine analogues: highly efficient synthesis and evaluation of DTPA-based MRI contrast enhancement agents

“…The optically active and racemic aziridinium ions 4b′ generated from β-bromoamines 3b were subjected to nucleophilic substitution reactions with pre-alkyated amine. First, ( rac )- 3b 18 was reacted with 15 22 to provide penta-alkylated triamines ( rac )- 16 as the regiospecific isomer. As expected, ring opening reaction of aziridnium ion ( rac )- 4b′ with 15 occurred at the less hindered methylene carbon in ( rac )- 4b′ .…”

Synthesis and Structures of Ruthenium and Iron Complexes Bearing an Unsymmetrical Pincer‐type Ligand with Protic Pyrazole and Tertiary Aminoalkyl Arms

“…We have recently demonstrated that the desymmetrized pyridinedicarboxylic acid derivative 1 9 can be converted to an unsymmetrical pincer‐type complex bearing a protic N‐heterocyclic carbene arm in addition to a pyrazole arm 4. The procedure was applied to the designed pincer‐type ligand LH ; amination of 1 and subsequent construction of the pyrazole ring successfully afforded LH in good yield, as summarized in Scheme .…”

“…Preparation of Methyl 6‐(Diethylaminomethyl)pyridine‐2‐carboxylate: To a solution of methyl 6‐(methylsulfonyloxymethyl)pyridine‐2‐carboxylate9 ( 1 ) (6.08 g, 24.8 mmol) in acetonitrile (200 mL) in an open flask was added diethylamine (2.56 mL, 24.8 mmol) and sodium carbonate (5.34 g, 50.4 mmol). The mixture was stirred for 16 h at 35 °C.…”

Reaction mechanism of NO with hydrolysates of NAMI‐A: an MD simulation by combining the QM/MM(ABEEM) with the MD‐FEP method

“…Thus, it is very interesting and necessary to explore the detailed mechanism of the nitrosylation of Ruthenium‐based drugs. NAMI‐A is reported in the literature to have high affinity for NO . The anti‐angiogenesis capability of NAMI‐A has been attributed to its ability of capturing NO, which is well documented in several experimental and theoretical studies …”