Rubella, cytomegalovirus and toxoplasmosis seroprevalence in pregnants in Çorum Province

KAHRAMAN, Hande; Savcı, Ünsal

doi:10.38053/acmj.1062754

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…In contrast, other researchers indicated that autistic cases had a significantly higher rate of CMV prevalence than healthy children (Kawashti et al 2006 ; Engman et al 2015 ; Sakamoto et al 2015 ). In the current study, CMV showed a high prevalence in both autistic and control groups, which conforms with previous reports suggesting a high prevalence of CMV seropositivity, especially in developing countries (Lachmann et al 2018 ; Arapović et al 2020 ; Kahraman and Savcı 2022 ).…”

Section: Discussionsupporting

confidence: 93%

“…Interestingly, both autistic and control children showed significantly higher CMV incidence than toxoplasmosis, which conforms to the reports of Mahic et al ( 2017 ), Frye et al ( 2019 ), and Kahraman and Savcı ( 2022 ). Despite the absence of any significant difference in the prevalence of Toxoplasma or CMV between the autistic and control groups, the autistic children documented a higher risk of infection than the control, which can be explained by the association with immune abnormalities in autistic children compared to the healthy ones, as reported previously (Raouf et al 2022 ).…”

Section: Discussionsupporting

confidence: 90%

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Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children

Hassan

Zekry²,

Heikal³

et al. 2023

Parasitol Res

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Autism is a neurodevelopmental disorder with a significantly increased incidence rate across the world over the past few years. Toxoplasmosis and cytomegalovirus (CMV) infection are globally prevalent and have been associated with diverse neurological and psychiatric disorders. A few studies have demonstrated the role of toxoplasmosis and CMV as potential etiological factors for autism. Accordingly, this study was performed to estimate the relationship between toxoplasmosis and CMV infection in children with autism as well as to assess their impact on the Childhood Autism Rating Scale (CARS) score. A total of 45 autistic children (6 girls, 39 boys) and 45 (21 girls, 24 boys) healthy control children were enrolled in our study. Their blood samples were collected and tested for the presence of Toxoplasma and CMV (IgG and IgM) antibodies and DNA by ELISA and real-time PCR (RT-PCR), respectively. Toxoplasmosis was detected in 11 (24.4%) autistic children through the ELISA [10 (22.2%) IgG + /IgM − and 1 (2.2%) IgG + /IgM +]; however, RT-PCR assay recorded only 1 positive case (2.2%), while it was detected in 10 (22.2%) control children through ELISA [9 (20%) IgG + /IgM − and 1 (2.2%) IgG + /IgM +] and 1 (2.2%) by RT-PCR. On the other hand, CMV infection was detected in all autistic children with 44 (97.8%) testing positive by ELISA [24 (53.3%) IgG + /IgM − , 18 (40%) IgG + /IgM + and 2 (4.4%) IgG − /IgM +] and 25 (55.6%) testing positive by RT-PCR assay. In addition, ELISA assay recorded 43 (95.6%) [19 (42.2%) IgG + /IgM + and 22 (48.9%) IgG + /IgM − and 2 (4.4%) IgG-/IgM +] and RT-PCR recorded 21 (46.7%) positive samples in control children with CMV. No significant difference was noted between autistic and control children for the overall prevalence of Toxoplasma or/and CMV infection. Similarly, the CARS score indicated a non-significant difference with Toxoplasma or/and CMV infection. Our data does not show an association between autism and toxoplasmosis or/and CMV infection. Nevertheless, considering that autistic children are at a high risk of contracting these infections, further studies with a larger sample size are recommended.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children

Hassan

Zekry²,

Heikal³

et al. 2023

Parasitol Res

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Investigation of Toxoplasma gondii Seroprevalence in Pregnant Women in Çankırı

Çamlıbel,

Yücesan,

Okur

et al. 2024

Comm. J. Biol.

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Toxoplasma gondii can be transmitted to humans through consumption of raw or undercooked meat containing live tissue cysts, consumption of water or food contaminated with oocysts shed from cat feces, and vertical transmission during pregnancy or through tissue, organ, and blood transfusion. The aim of this study was to investigate the seroprevalence of T. gondii in patients admitted to the Obstetrics and Gynecology Department of Çankırı State Hospital (ÇSH). In this study, anti-T. gondii IgG and IgM antibody levels of 62 pregnant women between the ages of 17 and 47 who applied to ÇSH gynecology and obstetrics outpatient clinic for normal pregnancy follow-up between June 2022 and January 2023 were investigated. According to the results of the studies, anti-T gondii IgG positivity is 12.9% and negative 87.1% and anti-T. gondii IgM positivity is 0% while it was found to be 100% negative. According to these results, it is reported that the majority of pregnant women do not encounter T. gondii and; therefore, they should be more careful in terms of congenital toxoplasmosis. T. gondii can be transmitted to humans through consumption of water or food contaminated with oocysts excreted in cat feces and through vertical transmission or tissue, organ, and blood transfusion during pregnancy. Therefore, pregnant women should be carefully monitored for T. gondii.

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Rubella, cytomegalovirus and toxoplasmosis seroprevalence in pregnants in Çorum Province

Cited by 2 publications

References 23 publications

Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children

Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children

Investigation of Toxoplasma gondii Seroprevalence in Pregnant Women in Çankırı

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