Rubella immune status among healthcare workers in the Department of Obstetrics and Gynaecology of a regional hospital in Hong Kong: the need for a vaccination policy

Chan, Paul K.S.; Li, C.Y.; Tam, Johnny; Cheng, A. F. B.

doi:10.1053/jhin.1999.0568

Cited by 14 publications

(8 citation statements)

References 8 publications

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“…However, as mentioned before, this program did not address the screening of women and women of reproductive age for the presence or absence of antimeasles and anti-rubella antibodies. Research Limitations ross-linking, resulting in hearing loss in patients (23). Due to the randomized sampling method used in this study, it was not possible to compare the subjects' immunity level in different parts of the city in terms of different socioeconomic levels.…”

Section: Resultsmentioning

confidence: 98%

A Review of Anti-Measles and Anti-Rubella Antibodies in 15 - 25 Year Old Women in Jahrom City In 2011

Rahmanian¹,

Mogharab²,

Mogharab³

2017

ME-JFM

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Introduction: Measles and rubella are acute viral diseases. Rubella often has mild clinical symptoms and cannot be diagnosed. Pregnant mother's infection with this disease causes serious complications, especially congenital rubella syndrome which is one of the causes of neonatal mortality, severe congenital defects and permanent disability in children. In contrast, measles often occurs with severe symptoms. This study aimed to determine the immunity level of Jahrom's young girls and women against measles and rubella 7 years after the public vaccination comparing to determine the percentage of infection with these two viruses, the effectiveness of the vaccine and an appropriate method to prevent the complications of these two diseases. Methodology: This study was a cross-sectional descriptive study. According to the previous study conducted one year after the public vaccination in Jahrom City, 100% of the subjects were given immune anti-rubella antibody titer and 94% received immune anti-measles antibody titer. Now this study measured anti-measles and anti-rubella antibody titers (IgG) in 180 women and girls aged 15-25 in Jahrom City through ELISA assay. Results: 165 subjects (91.7%) had positive rubella titer, 13 subjects (7.2%) had suspected rubella titer and 1 subject (0.6%) had negative rubella titer. Meanwhile, 170 subjects (94.4%) had positive, 6 subjects (13.3%) had suspected and 3 subjects (1.7%) had negative measles titer. Regarding suspected cases as positive for long-term maintenance of serums, a total of 98.5% of people were immunized measles and 97.5% were immunized rubella. With increase of age, antibody titer significantly increased (p<0.05). There was no significant relationship between taking or not taking steroids, immunity repressor and the subjects' immunity percentage (p<0.05). Conclusion: The results showed that although the national vaccinationcomparing in 2003 has been effective in immunizing the women of gestational age to measles and rubella, it seems that due to the gradual reduction of this immunity, all women, before pregnancy, should undergo a test to determine their immunity to these two diseases and if necessary, booster vaccine should be inoculated.

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Section: Resultsmentioning

confidence: 98%

A Review of Anti-Measles and Anti-Rubella Antibodies in 15 - 25 Year Old Women in Jahrom City In 2011

Rahmanian¹,

Mogharab²,

Mogharab³

2017

ME-JFM

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“…Among the healthy controls tested, 12.5% females and 5% males were found to be susceptible to rubella. Serosurvey among the healthcare personnel have revealed a seronegativity rate of 11.4% in India [Rajasundari et al, 2006] and 2.4-36.3% in various counties [Pruksananonda and Bumrungtrakul, 1983;Chan et al, 1999;Villasis-Keever et al, 2001;Fedeli et al, 2002]. These infected workers in turn can act as potential vectors in the transmission of the virus [Chan et al, 1999].…”

Section: Discussionmentioning

confidence: 99%

“…Serosurvey among the healthcare personnel have revealed a seronegativity rate of 11.4% in India [Rajasundari et al, 2006] and 2.4-36.3% in various counties [Pruksananonda and Bumrungtrakul, 1983;Chan et al, 1999;Villasis-Keever et al, 2001;Fedeli et al, 2002]. These infected workers in turn can act as potential vectors in the transmission of the virus [Chan et al, 1999]. Similar is the situation among pregnant women in the developing countries where there is wide variation in age specific seroprevalence of rubella ranging from 2.7% to 68% [Peckham et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Institutional outbreak of rubella in a healthcare center in Chandigarh, North India

Singh

Diddi

Dogra

et al. 2009

Journal of Medical Virology

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Rubella is traditionally considered a childhood disease but it has the potential to cause outbreaks in closed communities when a susceptible population accumulates. The present study reports an outbreak of rubella among healthcare workers in the pediatric center of a tertiary care North Indian hospital. The cases of rubella were identified by clinical features and confirmed by the detection of anti-rubella IgM antibodies in blood by enzyme linked immunosorbent assay. A total of 23 cases of rubella occurred over a period of one and a half month, out of which 9 (39%) were males. All the patients were in the age group of 21-35 years. None of the patients gave a history of rubella vaccination. This outbreak of rubella occurred due to the accumulation of a susceptible population in a closed hospital environment. There is need for the introduction of rubella vaccination in healthcare workers to prevent outbreaks at work place.

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“…It usually affects children. However, rubella outbreaks have also been reported in adults in closed communities as well as in hospital settings [Chan et al, ; Banatvala, ; Banerjee et al, ; Singh et al, ]. A herd immunity of ≥80% [Nardone et al, ; Dewan and Gupta, ] is required to prevent outbreaks, which usually occur in unimmunized population every 6 to 9 years due to accumulation of a large number of susceptible individuals [Gershon, ].…”

Section: Introductionmentioning

confidence: 99%

Rubella outbreak in the union territory of Chandigarh, North India

Singh

Kumar

Gautam

et al. 2014

Journal of Medical Virology

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Rubella virus outbreaks usually occur when a large numbers of susceptible individuals accumulate. The disease presents clinically with fever and maculopapular rash. The present study reports the investigation of rubella outbreak in a modern and well-planned village near Chandigarh, North India. The blood samples were collected from 39 cases with febrile rash and from 15 age and sex matched healthy controls residing in the same locality and subjected for the detection of Rubella IgM and IgG antibodies by Enzyme linked immunosorbent assay. The throat swabs, urine and blood samples from acute cases were also collected and subjected to RT-PCR using the primers targeting the E1 region. The genetic characterization of the rubella virus was carried out to identify the circulating genotypes. In the present outbreak, 13 laboratory confirmed cases were reported. Rubella IgM antibodies were detected in 12/39 (30.7%) patients. Rubella RNA could be detected in 83.3% (5/6) of urine, 22.2% (2/9) of throat swabs, and 8.3% (1/12) of blood samples. The rubella genotype responsible for the present outbreak was identified as genotype 1a. This outbreak highlights the need for the introduction of rubella vaccine in the National Immunization Programme of India to prevent outbreaks and to aim towards the eradication of this disease. This study reports the presence of genotype 1a in North India for the first time and stresses the need for further molecular work to identify the circulating strains of the virus.

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Rubella immune status among healthcare workers in the Department of Obstetrics and Gynaecology of a regional hospital in Hong Kong: the need for a vaccination policy

Cited by 14 publications

References 8 publications

A Review of Anti-Measles and Anti-Rubella Antibodies in 15 - 25 Year Old Women in Jahrom City In 2011

A Review of Anti-Measles and Anti-Rubella Antibodies in 15 - 25 Year Old Women in Jahrom City In 2011

Institutional outbreak of rubella in a healthcare center in Chandigarh, North India

Rubella outbreak in the union territory of Chandigarh, North India

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