Rubella in pregnancy: Intrauterine transmission and perinatal outcome during a Brazilian epidemic

Andrade, Júlio; Bunduki, Victor; Curti, Suely Pires; Figueiredo, Cristina; Oliveira, Maria Isabel de; Zugaib, Marcelo

doi:10.1016/j.jcv.2005.09.007

Cited by 39 publications

(32 citation statements)

References 13 publications

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“…2 Direct methods of diagnosing fetal infection by PCR are therefore essential for early diagnosis as shown by another report. 1 Our results showed that all pregnant women studied had positive serology results for IgG and IgM to rubella virus in the first or second sample. In the present cases, prenatal diagnosis was performed after 21 weeks of gestation and the time elapsed between the onset of maternal infection and the procedure was longer than 6 weeks, reducing false-negative results.…”

Section: Newborn Follow-upmentioning

confidence: 51%

“…However, infection during pregnancy, particularly during the first trimester, can lead to severe birth defects known as congenital rubella syndrome (CRS). 1 Congenital rubella infection causes fetal death and a spectrum of birth defects known as congenital rubella syndrome. The syndrome affects multiple organ systems and common abnormalities include deafness, congenital heart disease, cataracts and mental retardation.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 During the past 10 years, nationwide epidemics of rubella occurred approximately every 5 years in São Paulo, Brazil, namely in 1995, 2000 and 2007. 1,11 To reduce rubella transmission and prevent CRS, a nationwide campaign to vaccinate women and men against rubella was initiated in Brazil in 2001 and 2008. The World Health Organization (WHO) has estimated that more than 100,000 cases of CRS occur in developing countries every year; this represents a considerable social and economic burden.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal diagnosis of congenital rubella infection in São Paulo

Curti

Figueiredo

Oliveira

et al. 2014

Rev. Assoc. Med. Bras.

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Objective: rubella during the early stages of pregnancy can lead to severe birth defects known as congenital rubella syndrome (CRS). Samples collected from pregnant women with symptoms and suspected of congenital rubella infection between 1996 and 2008 were analyzed. Methods: a total of 23 amniotic fluid samples, 16 fetal blood samples, 1 product of conception and 1 placenta were analyzed by serology and RT-PCR. Results: all patients presented positive serology for IgG / IgM antibodies to rubella virus. Among neonates, 16 were IgG-positive, 9 were IgM-positive and 4 were negative for both antibodies. Of the 25 samples analyzed in this study, 24 were positive by RT-PCR. Changes in ultrasound were found in 15 (60%) of 25 fetuses infected with rubella virus. Fetal death and miscarriage were reported in 10 (40%) of the 25 cases analyzed. The rubella virus was amplified by PCR in all fetuses with abnormal ultrasound compatible with rubella. Fetal death and abortion were reported in 10 of 25 cases analyzed. Conclusion: this study, based on primary maternal rubella infection definitely confirms the good sensitivity and specificity of RT-PCR using amniotic fluid and ultrasound. The results showed that molecular assays are important tools in the early diagnosis of rubella and congenital rubella syndrome.

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Section: Newborn Follow-upmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal diagnosis of congenital rubella infection in São Paulo

Curti

Figueiredo

Oliveira

et al. 2014

Rev. Assoc. Med. Bras.

Self Cite

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show abstract

“…However, diagnosis of intrauterine infection is difficult because often maternal serology is inconclusive mainly when infection occurs between 13th and 20th weeks of gestations [Best, 2007]. Direct methods of diagnosing fetal infection by PCR are therefore essential for early diagnosis as shown by another report [Andrade et al, 2006]. This pregnant woman had no history of recent vaccination and probably had not been vaccinated.…”

Section: Discussionmentioning

confidence: 94%

Isolation and genotyping of rubella virus from a case of congenital infection in Brazil

Andrade

Figueiredo

Oliveira

et al. 2011

Journal of Medical Virology

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“…In babies, it can lead to congenital rubella syndrome characterized by growth retardation, cataracts, chorioretinitis, deafness, cardiac anomalies, hepatosplenomegaly, jaundice, thrombocytopenia, microcephaly and mental retardation especially if mothers were infected with rubella before 12 wk of gestation. 1,2 Because of routine vaccinations to prevent rubella, these anomalies are rarely seen today in developed countries. 2 However, in developing country such as India, MMR vaccine is not a part of the universal immunization programme though Indian Academy of Pediatrics recommends MMR vaccine in all children at 15 mo of age.…”

mentioning

confidence: 99%