Rubella infection in pregnancy

Santis, Marco De; Cavaliere, Anna Franca; Straface, Gianluca; Caruso, Alessandro

doi:10.1016/j.reprotox.2005.01.014

Cited by 152 publications

(75 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With maternal cytomegalovirus (CMV) infections, 30%-40% of fetuses become infected; of these, only about 12% develop signs and symptoms of congenital CMV syndrome, (51) while the risk of congenital rubella syndrome with first-trimester maternal infection could be greater than 50%. (52) From a population-level perspective, however, it is helpful to note that the absolute risk of a baby being born with microcephaly in an area with the highest incidence of ZIKV infections in Brazil is estimated to be only four in 1,000. …”

Section: Czs and Risk Of Vertical Transmissionmentioning

confidence: 99%

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

smedj

View full text Add to dashboard Cite

Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions. Although vertical transmission can occur at any time during gestation, first-and second-trimester infections have the highest risk of developing central nervous system anomalies. Aberrant fetal growth and pregnancy loss may also occur. Serial ultrasonography should be conducted for infected cases. Without a vaccine, pregnant women should be advised to minimise mosquito bites and reduce sexual transmission risk. Overall, the absolute risk of CZS arising amid a ZIKV outbreak appears relatively low.

show abstract

Section: Czs and Risk Of Vertical Transmissionmentioning

confidence: 99%

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

smedj

View full text Add to dashboard Cite

show abstract

“…The most common manifestations of CRS are congenital cataracts, sensorineural deafness, and congenital heart defects (especially PDA). When the heart is targeted, there is direct viral damage to the myocardium, affecting primarily the left atrium and the heart septa, leading to thrombosis, necrosis, and hemorrhage that cause of PDA, PS, and ASD (De Santis et al, 2006;Webster, 1998).  Maternal febrile illness; Influenza during the first trimester of pregnancy is associated with febrile illness, which appears to cause more right-sided obstructive heart defects, especially TA and PA, some left obstructive defects and VSD (Oster et al, 2011;Yu et al, 2008;.…”

Section: Maternal Connective Tissue Diseases;mentioning

confidence: 99%

Epidemiology and Etiology of Congenital Heart Diseases

Sayasathid¹,

Sukonpan²,

Somboonna³

2012

Congenital Heart Disease - Selected Aspects

View full text Add to dashboard Cite

“…Evidence for programming is well established in animals (3) and exposures in humans, such as Rubella infection in utero (4) and inadequate periconceptual folate (5) can also result in structural changes (these might be described as teratogenic effects). However, the relevance of less extreme exposures in humans and their ability to induce adaptive responses is less clear.…”

mentioning

confidence: 99%

Modifiable Maternal Exposures and Offspring Blood Pressure: A Review of Epidemiological Studies of Maternal Age, Diet, and Smoking

et al. 2008

View full text Add to dashboard Cite

Prenatal programming of adult disease is well established in animals. In humans the impact of common in utero exposures on long-term offspring health is less clear. We reviewed epidemiology studies of modifiable maternal exposures and offspring blood pressure (BP). Three maternal exposures were identified for review and meta-analyzed where possible: smoking during pregnancy, diet, and age at childbirth. Meta-analysis suggested there was a modest association between higher offspring BP and prenatal exposure to smoke (confounder-adjusted ␤ ϭ 0.62 mm Hg, 95% confidence interval: 0.19 -1.05, I 2 ϭ 16.4%). However, the level of confounder adjustment varied between studies, which in some studies attenuated the association to the null. There was no strong evidence that any component of maternal diet during pregnancy (maternal protein, energy, calcium, and various other nutrients) influences offspring BP. The results of studies of maternal age varied and there was strong evidence of heterogeneity in the pooled analysis. The association with maternal age, if present, was modest (confounderadjusted ␤ ϭ 0.09 mm Hg/y, 95% confidence interval: Ϫ0.03 to 0.21, I 2 ϭ 89.8%). In sum, there is little empirical evidence that the maternal exposures reviewed program offspring BP. Other components of offspring health may be more susceptible to effects of programming in utero. (Pediatr Res 63: 593-598, 2008) P rogramming has been defined as to the process by which a stimulus occurring during a sensitive period of development has lasting effects on development or risk of disease (1,2). Evidence for programming is well established in animals (3) and exposures in humans, such as Rubella infection in utero (4) and inadequate periconceptual folate (5) can also result in structural changes (these might be described as teratogenic effects). However, the relevance of less extreme exposures in humans and their ability to induce adaptive responses is less clear.Interest in the role of early life and later chronic disease developed from early ecological studies by Forsdahl (6) linking infant mortality to subsequent cardiovascular disease mortality. Later studies by Barker and colleagues (1), showing that size at birth was related to adult chronic disease, extended this interest to intrauterine programming. Blood pressure (BP) is strongly and directly associated with mortality from cardiovascular disease (7), and the evidence for associations of low birth weight with adverse outcomes in later life is robust for BP (8) [although this has been disputed (9)]. In addition, there are strong cohort effects for secular changes in BP providing evidence for a role of early exposures (10,11). Thus, we have focused on BP in this review.There are various possible explanations for the association between low birth weight and later disease. These include confounding by socioeconomic position (SEP) (12), shared genes (13) and adjustment for later body size that represents programming in infancy or later in development (14). However, the association be...

show abstract

Rubella infection in pregnancy

Cited by 152 publications

References 115 publications

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Epidemiology and Etiology of Congenital Heart Diseases

Modifiable Maternal Exposures and Offspring Blood Pressure: A Review of Epidemiological Studies of Maternal Age, Diet, and Smoking

Contact Info

Product

Resources

About