Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway

Geng, Chang‐An; Chen, Fengyang; Zheng, Jing-Bin; Liao, Ping; Li, Tianze; Zhang, Xuemei; Chen, Xin; Chen, Ji‐Jun

doi:10.1016/j.phymed.2023.154898

Cited by 4 publications

(1 citation statement)

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“…Increased levels of Treg cells have been detected in the peripheral blood, the primary tumor microenvironment, and the draining lymph nodes of cancer patients (103)(104)(105). Therefore, interventions targeting Treg cells have become the new strategy of many therapies for malignant tumors (106,107). Radix Glycyrrhizae is a commonly used traditional Chinese herbal medicine with a wide range of pharmacological functions throughout Chinese history, and the polysaccharide is a major active compound extracted from it, which is cytotoxic to cancer cells (108,109).…”

Section: Radix Glycyrrhizae Polysaccharidementioning

confidence: 99%

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Liu,

Wu,

Hao

2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder the immune response and lead to a state of immune suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. This review aims to look into the immunomodulatory effects of TCM polysaccharides on HCC. The immunomodulatory effects of TCM polysaccharides are primarily manifested through the activation of effector T lymphocytes, dendritic cells, NK cells, and macrophages against hepatocellular carcinoma (HCC) both in vivo and in vitro settings. Furthermore, TCM polysaccharides have demonstrated remarkable adjuvant antitumor immunomodulatory effects on HCC in clinical settings. Therefore, the utilization of TCM polysaccharides holds promising potential for the development of novel therapeutic agents or adjuvants with advantageous immunomodulatory properties for HCC.

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