[RuII(η5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin

Hydrogen Bonding and Anticancer Properties of Water‐Soluble Chiral p‐Cymene RuII Compounds with Amino‐Oxime Ligands

“…While starting organometallic and proligand products are poorly cytotoxic (IC 50 > 170 µM), the water soluble ruthenium amino-oxime compound shows considerable higher cytotoxicity than cisplatin (51 ± 0.10 µM, under the same experimental conditions [68,69] ).…”

[(η6-p-cymene)Ru(H2O)3]2+ binding capability of aminohydroxamates — A solution and solid state study

“…Earlier studies mostly dealt with the design, synthesis, characterization and biological test of these [(η 6 -arene)Ru(XY)Z] type (arene = benzene(derivative), XY = chelating, Z = monodentate ligand) complexes. [6][7][8][9][10] Recent years research focusing on their solution behaviour or the interaction with various high [11][12][13][14][15][16][17] or low molecular mass [18][19][20][21][22][23][24][25][26][27][28][29] biomolecules is also in progress.…”

The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds

“…is Ru(1)-P(1) = 2.3021(5) Å, and distances for Ru-N bonds are Ru(1)-N(1) 2.0731(14) Å and Ru(1)-N(2) 2.0712(14) Å. The distance between Ru and the centroid of the π-bonded cyclopentadienyl moiety is 1.821 Å to Ru centre (ring slippage 0.045 Å).…”