2016
DOI: 10.1371/journal.pone.0166905
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Rule-Mining for the Early Prediction of Chronic Kidney Disease Based on Metabolomics and Multi-Source Data

Abstract: 1H Nuclear Magnetic Resonance (NMR)-based metabolic profiling is very promising for the diagnostic of the stages of chronic kidney disease (CKD). Because of the high dimension of NMR spectra datasets and the complex mixture of metabolites in biological samples, the identification of discriminant biomarkers of a disease is challenging. None of the widely used chemometric methods in NMR metabolomics performs a local exhaustive exploration of the data. We developed a descriptive and easily understandable approach… Show more

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Cited by 20 publications
(21 citation statements)
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“…For the supervised analysis, we used a rule-miming based approach that combines a supervised variable selection step and a classification step (Luck et al 2016 ). The rationale for the use of this approach is to avoid overfitting and provide more precise information compared to conventional methods.…”
Section: Methodsmentioning
confidence: 99%
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“…For the supervised analysis, we used a rule-miming based approach that combines a supervised variable selection step and a classification step (Luck et al 2016 ). The rationale for the use of this approach is to avoid overfitting and provide more precise information compared to conventional methods.…”
Section: Methodsmentioning
confidence: 99%
“…The variable selection step is based on the combination of two univariate approaches: a global one, based on the χ 2 test (Scikit-learn project implementation (Pedregosa et al 2011 )), and a local one, based on a supervised rule mining algorithm (in-house implementation) (Luck et al 2015 , 2016 ). The global approach first selected variables with a chi2 test significant p value < 0.05 leading to a subset of variables.…”
Section: Methodsmentioning
confidence: 99%
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“…4,5 A growing body of preclinical and clinical research is evaluating novel approaches to pharmacological nephroprotection that may become available for children with CKD in the foreseeable future. 6,7 …”
mentioning
confidence: 99%
“…This diversity may have helped in identifying a robust common denominator. Enhanced branched-chain amino acids and a reduction in citrate excretion has been reported previously, but for other nephropathies including chronic kidney disease, [39,40], diabetic nephropathy [41] and polycystic kidney disease [42]. They may be signs of early kidney damage, as a reduction of citrate can be a sign for mitochondrial dysfunction of the proximal tubular cell [24].…”
Section: Discussionmentioning
confidence: 65%