Rumex dentatus L. phenolics ameliorate hyperglycemia by modulating hepatic key enzymes of carbohydrate metabolism, oxidative stress and PPARγ in diabetic rats

Elsayed, Rasha H.; Kamel, Emadeldin M.; Mahmoud, Ayman M.; El-Bassuony, Ashraf A.; Bin-Jumah, May; Lamsabhi, Al Mokhtar; Ahmed, Sayed A.

doi:10.1016/j.fct.2020.111202

Cited by 38 publications

(29 citation statements)

References 95 publications

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“…This residue plays a crucial role in the regulation of PPARγ expression. [ 66 ] Phe226 is capable of making favorable π–π interactions that could potentially stabilize the pi interactions with the ligand.…”

Section: Discussionmentioning

confidence: 99%

Visnagin prevents isoproterenol‐induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats

Abukhalil

Hussein

Aladaileh

et al. 2021

J Biochem & Molecular Tox

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Oxidative tissue injury and inflammatory responses play major roles in cardiovascular diseases and heart failure. Visnagin (VIS) is a natural bioactive component of Ammi visnaga, with promising radical scavenging and anti‐inflammatory activities. This study explored the protective effect of VIS against isoproterenol (ISO)‐induced acute myocardial injury and oxidative stress in rats. VIS was supplemented for 14 days, and the rats received ISO (100 mg/kg) twice at an interval of 24 h. ISO‐induced myocardial injury was characterized by elevated serum CK‐MB, LDH, and troponin‐I associated with increased heart weight and several histopathological changes. ISO increased reactive oxygen species (ROS), malondialdehyde (MDA), NF‐κB p65, TNF‐α, IL‐6, and decreased glutathione and antioxidant enzymes in rats' hearts. VIS prevented myocardial injury and ameliorated the cardiac function markers, ROS, MDA, NF‐κB p65, and pro‐inflammatory cytokines in ISO‐intoxicated rats. In addition, VIS decreased Bax mRNA and caspases, and upregulated Nrf2, HO‐1, Bcl‐2, and PPARγ. Molecular docking simulations revealed the binding method of VIS to NF‐κB, Keap1, and PPARγ. In conclusion, VIS protects against ISO‐induced acute myocardial injury by attenuating oxidative tissue injury and reducing key inflammatory and apoptosis markers. In vivo and in silico results showed that activation of Nrf2/HO‐1 signaling and PPARγ mediates the cardioprotective effect of VIS.

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Section: Discussionmentioning

confidence: 99%

Visnagin prevents isoproterenol‐induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats

Abukhalil

Hussein

Aladaileh

et al. 2021

J Biochem & Molecular Tox

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“…Resveratrol (139), (Z)-resveratrol (140) and polydatin (141) were obtained from Rumex spp. [14,32,35,45,110,111]. 5,4'-Dihydroxy-3-methoxystilbene (142), 3,5-dihydroxy-4'-methoxystilbene (143) and 5,4'-dihydroxy-stilbene-3-O-α-arabinoside (144) were separated from the roots of R. bucephalophorus [77].…”

Section: Stilbenesmentioning

confidence: 99%

“…To date, 268 components from 29 Rumex species have been reported. Anthraquinones, flavonoids, tannins, stilbenes, naphthalenes, diterpene alkaloids, terpenes, and lignans were as the main chemical components, with a broad spectrum of pharmacological activities, such as anti-inflammatory, antioxidant, antibacteria, antitumor, and antidiabetic activities [13][14][15][16][17]. In addition to important role of Rumex in the traditional applications, researchers also regard Rumex as a potential effective medicine of many diseases.…”

Section: Introductionmentioning

confidence: 99%

The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review

et al. 2022

Nat. Prod. Bioprospect.

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Rumex L., a genus in Polygonaceae family with about 200 species, is growing widely around the world. Some Rumex species, called "sorrel" or "dock", have been used as food application and treatment of skin diseases and hemostasis after trauma by the local people of its growing areas for centuries. To date, 29 Rumex species have been studied to contain about 268 substances, including anthraquinones, flavonoids, naphthalenes, stilbenes, diterpene alkaloids, terpenes, lignans, and tannins. Crude extract of Rumex spp. and the pure isolates displayed various bioactivities, such as antibacterial, anti-inflammatory, antitumor, antioxidant, cardiovascular protection and antiaging activities. Rumex species have important potential to become a clinical medicinal source in future. This review covers research articles from 1900 to 2022, fetched from SciFinder, Web of Science, ResearchGate, CNKI and Google Scholar, using “Rumex” as a search term ("all fields") with no specific time frame set for the search. Thirty-five Rumex species were selected and summarized on their geographical distribution, edible parts, traditional uses, chemical research and pharmacological properties.

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“…Oxidative stress can cause a significant decrease in average body weight gain, food intake, and food efficiency ratios in rats compared with NSF. Oxidative stress condition causes inflammation, decreased insulin production, and impaired insulin signaling ( Elsayed et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Analog Rice Derived from Different Composite Flours from Tubers, Germinated Legumes, and Cereals on Improving Serum Markers in Alloxan-Induced Diabetic Rats

Nugraheni

Purwanti

Ekawatiningsih

2021

Prev. Nutr. Food Sci.

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This study aimed to evaluate the consumption of four types of analog rice made from different composite flours in alloxan-induced diabetic rats. Forty-two male Wistar rats were divided into seven groups and fed different food for six weeks: normal standard food (NSF), diabetic standard food (DSF), diabetic commercial rice (DCR), and diabetic analog rice (DAR) I∼IV. Total phenolic, dietary fiber, and resistant starch contents were evaluated in every analog and commercial type of rice. The parameters studied were fasting blood glucose, homeostatic model assessment (HOMA) insulin resistance (IR), HOMA β, lipid profile, atherogenic indexes (AI), weight changes, serum insulin and antioxidant activities. Total phenol, dietary fiber, and resistant starch were higher for analog rice IV than the other three analog rice. In addition, analog rice IV had a greater ability to lower fasting blood glucose, total cholesterol, triglycerides, and low-density lipoprotein levels. High density lipoprotein levels increased in all groups fed analog rice, and all diabetic rats fed four types of analog rice had improved weight, antioxidant activity, serum insulin levels, HOMA IR, HOMA β, and AI. Commercial rice consumption did not improve glucose or lipids profiles, antioxidant activity, serum insulin level, HOMA IR, HOMA β, or AI in diabetic mice. These results show that the four types of analog rice significantly improved serum markers in diabetic rats.

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Rumex dentatus L. phenolics ameliorate hyperglycemia by modulating hepatic key enzymes of carbohydrate metabolism, oxidative stress and PPARγ in diabetic rats

Cited by 38 publications

References 95 publications

Visnagin prevents isoproterenol‐induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats

Visnagin prevents isoproterenol‐induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats

The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review

Impact of Analog Rice Derived from Different Composite Flours from Tubers, Germinated Legumes, and Cereals on Improving Serum Markers in Alloxan-Induced Diabetic Rats

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