Rumex usambarensis (Dammer) Leaf and Stem Extract Effect on Body Weight and Lipid Profile: A Study in Albino Rats

Hilda, Nattabi; Nkwangu, David; Engeu, Ogwang Patrick

doi:10.9734/bjpr/2016/27409

Cited by 2 publications

(7 citation statements)

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“…This finding is in agreement with that of a study by Hilda et al, which also reported a weight loss effect of the aqueous extract. 19 This could be attributed to the presence of alkaloids and saponins in the aqueous extract of Rumex usambarensis , which have shown to have some weight reduction activity. 19 , 24–26 …”

Section: Discussionmentioning

confidence: 99%

“… 19 This could be attributed to the presence of alkaloids and saponins in the aqueous extract of Rumex usambarensis , which have shown to have some weight reduction activity. 19 , 24–26 …”

Section: Discussionmentioning

confidence: 99%

“…20 In Uganda, particularly in western Uganda, herdsmen commonly chew raw stems and leaves as snacks due to their salty taste, as they herd cattle, and it is believed to reduce hunger; a previous study showed that the aqueous extract has an effect on weight and lipid profiles. 19 The aim of this study, therefore, was to determine the effect of Rumex usambarensis leaf and stem aqueous extract on appetite, as a possible mechanism by which it causes weight loss.…”

Section: Introductionmentioning

confidence: 99%

“…It grows commonly in the montane grassland, open mist forest, bushland, exposed rocky slopes and woodlands but also near swamps in lowlands, at elevations from 800 to 2400 meters. [17][18][19] The plant is usually harvested from the wild as a local source of food and medicine. Young leaves and stems of the plant are taken raw, and due to their salty flavor, the plant is usually picked from the wild to eat as a snack.…”

Section: Introductionmentioning

confidence: 99%

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Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study

Atwiine,

Mwesigwa,

Mwesiga

et al. 2024

JEP

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Background The burden of obesity and overweight associated morbidity and mortality is increasing in epidemic proportions worldwide. Suppression of appetite is one of the mechanisms that has been shown to reduce weight. Most of the drugs on the market currently for appetite suppression are not readily available or affordable in resource-limited settings. Additionally, previous studies have shown that most of these drugs are associated with significant adverse effects, which demonstrates a need for alternative or complementary options of drugs for appetite suppression. In Uganda, herdsmen commonly chew the raw stems and leaves of Rumex usambarensis, a wild shrub, and this is believed to reduce hunger. This study aimed at determining the effect of Rumex usambarensis aqueous extract on food intake as a measure of appetite in Wistar albino rats. Methods This study was carried out in two phases: the fattening phase and the treatment phase. Female albino Wistar rats were fed a high-fat diet for 49 days. The fattened animals were then randomly separated into 4 groups, which received 1 mL of distilled water (negative control), 500 mg/kg body weight of aqueous extract of Rumex usambarensis, 1000 mg/kg body weight of the extract and 20 mg/kg body weight topiramate (positive control), respectively. Food intake was measured every day, and weights were taken every two days for every group. Results Rumex usambarensis extract significantly reduced body weight of fattened rats compared to the control group at both doses: for the 500mg/kg dose (Mean difference, MD = 17.2, p < 0.001) and for 1000mg/kg dose (MD = 25.9, p < 0.001). Additionally, both doses of the aqueous extract showed a significant reduction in food intake: for the 500mg/kg dose (MD = 16.1, p < 0.001) and for the 1000mg/kg dose (MD = 37.3, p < 0.001). There was a strong correlation between food intake and weight for both doses for the 500mg/kg dose (r = 0.744, p = 0.009), and the strongest association observed with 1000mg/kg dose (r = 0.906, p < 0.001). Conclusion The aqueous extract of the leaves and stems of Rumex usambarensis has appetite suppressing and weight reduction effects in fattened female Wistar albino rats and could be an efficacious alternative medicine for management of overweight, obesity and other related disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study

Atwiine,

Mwesigwa,

Mwesiga

et al. 2024

JEP

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“…Only a portion of the multiple indications provided by ethnopharmacological reports have been scientifically scrutinized and, in most cases, limited attention has been paid to phytochemical content and to the correlation between bioactivities and profiling. Furthermore, no differential evaluations of different plant organs were made [ 16 , 20 ]. As reported by Vasas et al in their recent and comprehensive review of the ethnopharmacological knowledge of Rumex genus, most bioactivity studies were conducted on poorly characterized extracts, thus affecting both repeatability and further investigations aimed at maximizing the reported effects [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant

Spaggiari

Righetti

Spadini

et al. 2023

Plants

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The comprehensive identification of secondary metabolites represents a fundamental step for the assessment of bioactivities and pharmacological properties of traditional herbal drugs. Rumex usambarensis (Dammer) Dammer has been described as a multipurpose remedy in different African traditional pharmacopoeias, but its phytochemical profile has not been properly investigated. Herein we report a high throughput metabolomic screening, based on ultra-high performance liquid chromatography-travelling wave ion mobility spectrometry quadrupole time-of-flight (UHPLC-TWINS-QTOF), which was performed for the first time on different R. usambarensis plant parts. By applying high-resolution mass spectrometry-based metabolomics and chemometric analysis, a complete discrimination of different aerial parts was obtained, with the annotation of 153 significant metabolites in leaves, stems, and flowers, suggesting an easy authentication and discrimination route. Phytochemical data were correlated to antimicrobial and antioxidant properties. Flavonoids, benzopyranes, chromones, and xanthones derivatives, along with a richer phytocomplex, might be responsible for the stronger bioactivities obtained from flowers.

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Rumex usambarensis (Dammer) Leaf and Stem Extract Effect on Body Weight and Lipid Profile: A Study in Albino Rats

Cited by 2 publications

References 0 publications

Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study

Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study

Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant

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