Ruminal microbiota–host interaction and its effect on nutrient metabolism

Zhang, Yangdong; Yu, Zhongtang; Xu, Qingbiao; Zheng, Nan; Zhao, Shengguo; Huang, Guoxin; Wang, Jiaqi

doi:10.1016/j.aninu.2020.12.001

Cited by 88 publications

(52 citation statements)

References 57 publications

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“…It has been documented that the dietary energy level could profoundly affect the gut microbiota and thus result in the changes in nutrient digestibility, microbial protein synthesis, and milk production parameters by intervening in the ruminal microbial community (6). The structure of the ruminal microbiome determines the ability to extract energy from feed ingredients (7,8). However, how the dietary energy level affects the gut microbiota and growth performance of donkeys remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome

Zhang

Wang

et al. 2021

Front. Vet. Sci.

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Considerable evidence suggests that dietary energy levels and gut microbiota are pivotal for animal health and productivity. However, little information exists about the correlations among dietary energy level, performance, and the gut microbiota and metabolome of donkeys. The objective of this study was to investigate the mechanisms by which dietary energy content dictates the growth performance by modulating the intestinal microbiome and metabolome of donkeys. Thirty-six nine-month-old male Dezhou donkeys with similar body weights were randomly assigned to two groups fed low- or high-energy diets (LE or HE). The results showed that donkeys fed HE had increased (p < 0.05) the average daily gain (ADG) and feed efficiency (G/F) compared with those that received LE diet. The gut microbiota in both groups was dominated by the phyla Firmicutes and Bacteroidetes regardless of the dietary energy level. However, feeding HE to donkeys significantly decreased (p < 0.05) the ratio of Firmicutes to Bacteroidetes (F/B). Compared to the LE group, feeding HE specifically increased the abundances of unidentified_Prevotellaceae (p = 0.02) while decreasing the richness of unidentified_Ruminococcaceae (p = 0.05). Compared to the LE group, feeding the HE diet significantly (p < 0.05) upregulated certain metabolic pathways involving the aspartate metabolism and the urea cycle. In addition, the increased bacteria and metabolites in the HE-fed group exhibited a positive correlation with improved growth performance of donkeys. Taken together, feeding the HE diet increased the richness of Prevotellaceae and upregulated growth-related metabolic pathways, which may have contributed to the ameliorated growth performance of donkeys. Thus, it is a recommendable dietary strategy to feed HE diets to fattening donkeys for superior product performance and feed efficiency.

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Section: Introductionmentioning

confidence: 99%

Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome

Zhang

Wang

et al. 2021

Front. Vet. Sci.

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“…The ruminants' gastrointestinal tract is estimated to inhabit over 5000 microorganism species [62], with the rumen, described as the ruminants' "Black Box" [63], having the most diversified population of anaerobic bacteria, fungi, archaea, protozoa, and viruses [64]. Various health challenges could stem from an unhealthy or imbalanced gut microbiome.…”

Section: Multistrain Probiotic Use In Ruminantsmentioning

confidence: 99%

The Recent Trend in the Use of Multistrain Probiotics in Livestock Production: An Overview

Lambo

Chang

Dasen

2021

Animals

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It has been established that introducing feed additives to livestock, either nutritional or non-nutritional, is beneficial in manipulating the microbial ecosystem to maintain a balance in the gut microbes and thereby improving nutrient utilization, productivity, and health status of animals. Probiotic use has gained popularity in the livestock industry, especially since antimicrobial growth promoter’s use has been restricted due to the challenge of antibiotic resistance in both animals and consumers of animal products. Their usage has been linked to intestinal microbial balance and improved performance in administered animals. Even though monostrain probiotics could be beneficial, multistrain probiotics containing two or more species or strains have gained considerable attention. Combining different strains has presumably achieved several health benefits over single strains due to individual isolates’ addition and positive synergistic adhesion effects on animal health and performance. However, there has been inconsistency in the effects of the probiotic complexes in literature. This review discusses multistrain probiotics, summarizes selected literature on their effects on ruminants, poultry, and swine productivity and the various modes by which they function.

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“…The reticulorumen appears to be a multifunctional fermentation sac with sizes varying from cattle (35-100 L) and sheep (3-5 L) (7). The physicochemical parameters of the rumen are described in Table 1 (9)(10)(11)(12)(13). The host organism maintains the environment of rumen through various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Their Role in Health and Metabolic Disease of Dairy Cow

Qiao

Gao

et al. 2021

Front. Nutr.

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Ruminants are mostly herbivorous animals that employ rumen fermentation for the digestion of feed materials, including dairy cows. Ruminants consume plant fibre as their regular diet, but lack the machinery for their digestion. For this reason, ruminants maintain a symbiotic relation with microorganisms that are capable of producing enzymes to degrade plant polymers. Various species of microflora including bacteria, protozoa, fungi, archaea, and bacteriophages are hosted at distinct concentrations for accomplishing complete digestion. The ingested feed is digested at a defined stratum. The polysaccharic plant fibrils are degraded by cellulolytic bacteria, and the substrate formed is acted upon by other bacteria. This sequential degradative mechanism forms the base of complete digestion as well as harvesting energy from the ingested feed. The composition of microbiota readily gets tuned to the changes in the feed habits of the dairy cow. The overall energy production as well as digestion is decided by the intactness of the resident communal flora. Disturbances in the homogeneity gastrointestinal microflora has severe effects on the digestive system and various other organs. This disharmony in communal relationship also causes various metabolic disorders. The dominance of methanogens sometimes lead to bloating, and high sugar feed culminates in ruminal acidosis. Likewise, disruptive microfloral constitution also ignites reticuloperitonitis, ulcers, diarrhoea, etc. The role of symbiotic microflora in the occurrence and progress of a few important metabolic diseases are discussed in this review. Future studies in multiomics provides platform to determine the physiological and phenotypical upgradation of dairy cow for milk production.

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Ruminal microbiota–host interaction and its effect on nutrient metabolism

Cited by 88 publications

References 57 publications

Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome

Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome

The Recent Trend in the Use of Multistrain Probiotics in Livestock Production: An Overview

Gut Microbiota and Their Role in Health and Metabolic Disease of Dairy Cow

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