Ruminiclostridium 5, Parabacteroides distasonis, and bile acid profile are modulated by prebiotic diet and associate with facilitated sleep/clock realignment after chronic disruption of rhythms

Thompson, Robert S.; Gaffney, Michelle; Hopkins, Shelby; Kelley, T. P.; González, Antonio; Bowers, Samuel J.; Vitaterna, Martha Hotz; Turek, Fred W.; Foxx, Christine L.; Lowry, Christopher A.; Vargas, Fernando; Dorrestein, Pieter C.; Wright, Kenneth P.; Knight, Rob; Fleshner, Monika

doi:10.1016/j.bbi.2021.07.006

Cited by 50 publications

(49 citation statements)

References 105 publications

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“…The prebiotic diet did not impact baseline sleep, yet, surprisingly, promoted increased non-rapid eye movement (NREM) and rapid eye movement (REM) sleep during the sleep deprivation protocol as well as increased total sleep during recovery. These sleep changes were positively correlated with the relative abundance of the bacterium Parabacteroides distasonis , which we and others have previously shown to be increased by GOS/PDX supplementation and which may promote resilience in the setting of physiologic challenges such as chronic disruption of circadian rhythms ( Thompson et al, 2021 ). An analysis of fecal bile acids demonstrated associations with P. distasonis and other bacteria impacted by the prebiotic diet, suggesting a potential mechanism by which the prebiotic diet may exert physiologic effects.…”

Section: Introductionmentioning

confidence: 51%

“…One such approach is via dietary supplementation with prebiotics, which are compounds neither absorbed nor actively metabolized by human hosts but are selective substrates for intestinal bacteria thought to be beneficial ( Manning and Gibson, 2004 ). Galactooligosaccharides (GOS) and polydextrose (PDX) are examples of prebiotics that have been shown to impact physiological processes in different model systems ( Macfarlane et al, 2008 ; Do Carmo et al, 2016 ), including a recent report showing that GOS/PDX supplementation in rats accelerates recovery in response to environmental disruption of circadian rhythms ( Thompson et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats

et al. 2022

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Sleep disruption is a challenging and exceedingly common physiological state that contributes to a wide range of biochemical and molecular perturbations and has been linked to numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, including exposure to electric light, psychological stressors, technological interconnection, jet travel, shift work, and widespread use of sleep-affecting compounds. Interestingly, recent research has identified a link between the microbiome and the regulation of sleep, suggesting that interventions targeting the microbiome may offer unique therapeutic approaches to challenges posed by sleep disruption. In this study, we test the hypothesis that administration of a prebiotic diet containing galactooligosaccharides (GOS) and polydextrose (PDX) in adult male rats improves sleep in response to repeated sleep disruption and during recovery sleep. We found that animals fed the GOS/PDX prebiotic diet for 4 weeks exhibit increased non-rapid eye movement (NREM) and rapid eye movement (REM) sleep during 5 days of sleep disruption and increased total sleep time during 24 h of recovery from sleep disruption compared to animals fed a control diet, despite similar baseline sleep characteristics. Further, the GOS/PDX prebiotic diet led to significant changes in the fecal microbiome. Consistent with previous reports, the prebiotic diet increased the relative abundance of the species Parabacteroides distasonis, which positively correlated with sleep parameters during recovery sleep. Taken together, these findings suggest that the GOS/PDX prebiotic diet may offer an approach to improve resilience to the physiologic challenge of sleep disruption, in part through impacts on the microbiome.

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Section: Introductionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats

et al. 2022

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“…Ruminiclostridium is a strictly anaerobic bacterium known for its decomposition activity [ 31 ]. Although their effects on the host physiology have not been extensively studied, a prebiotic diet has found a rapid and steady increase in the relative abundance of Ruminiclostridium 5, positively correlated with the concentration of bile acids in feces [ 32 , 33 ]. Our current results, combined with previous research results, show that SCS can promote a healthy gut microbial ecology.…”

Section: Resultsmentioning

confidence: 99%

Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice

Shen

et al. 2022

IJMS

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Chondroitin sulfate (CS) is a well-known bioactive substance with multiple biological functions, which can be extracted from animal cartilage or bone. Sturgeon, the largest soft bone animal with ~20% cartilage content, is a great candidate for CS production. Our recent study confirmed the role of sturgeon chondroitin sulfate (SCS) in reducing colorectal cancer cell proliferation and tumor formation. Here, we further studied the effect of SCS on modulating gut microbiome structure in colorectal cancer bearing mice. In this study, the transplanted tumor mice model was constructed to demonstrate that SCS can effectively halt the growth of transplanted colorectal tumor cells. Next, we showed that SCS significantly altered the gut microbiome, such as the abundance of Lactobacillales, Gastranaerophilales, Ruminiclostridiun_5 and Ruminiclostridiun_6. According to linear discriminant analysis (LDA) and abundance map analysis of the microbial metabolic pathways, the changes in microbial abundance led to an increase of certain metabolites (e.g., Phe, Tyr, and Gly). Fecal metabolome results demonstrated that SCS can significantly reduce the amount of certain amino acids such as Phe, Pro, Ala, Tyr and Leu presented in the feces, suggesting that SCS might inhibit colorectal cancer growth by modulating the gut microbiome and altering the production of certain amino acids. Our results revealed the therapeutic potential of SCS to facilitate treatment of colorectal cancer. This study provides insights into the development of novel food-derived therapies for colorectal cancer.

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“…Low abundance of Firmicutes microbiota can increase intestinal sensitivity to inflammation [ 59 , 60 , 61 ], suggesting that taxifolin could play an anti-inflammatory role in the intestinal tract by regulating intestinal microbiota imbalance. More importantly, a large number of the top 20 genera, 8 beneficial bacteria were significantly enriched after Taxifolin treatment, and 6 of them belong to SCFA-producing bacteria, such as Ruminiclostridium_5 , Bacteroides , Lachnospiraceae_NK4A136_group , Lactobacillus , Ruminococcaceae_UCG-014 , [ Eubacterium]_coprostanoligenes_group [ 62 , 63 , 64 , 65 , 66 , 67 ]. It has been reported that SCFA-producing bacteria can benefit the host by inhibiting the expression of inflammatory factors, providing nutritional levels to colon cells, and enhancing tight junction protein expression [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid

Zhang

et al. 2022

Nutrients

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Taxifolin is a bioflavonoid which has been used to treat Inflammatory Bowel Disease. However, taxifolin on DSS-induced colitis and gut health is still unclear. Here, we studied the effect of taxifolin on DSS-induced intestinal mucositis in mice. We measured the degree of intestinal mucosal injury and inflammatory response in DSS treated mice with or without taxifolin administration and studied the changes of fecal metabolites and intestinal microflora using 16S rRNA. The mechanism was further explored by fecal microbiota transplantation. The results showed that the weight loss and diarrhea score of the mice treated with taxifolin decreased in DSS-induced mice and longer colon length was displayed after taxifolin supplementation. Meanwhile, the expression of GPR41 and GPR43 in the colon was significantly increased by taxifolin treatment. Moreover, the expression of TNF-α, IL-1β, and IL-6 in colon tissue was inhibited by taxifolin treatment. The fecal metabolism pattern changed significantly after DSS treatment, which was reversed by taxifolin treatment. Importantly, taxifolin significantly increased the levels of butyric acid and isobutyric acid in the feces of DSS-treated mice. In terms of gut flora, taxifolin reversed the changes of Akkermansia, and further decreased uncultured_bacterium_f_Muribaculaceae. Fecal transplantation from taxifolin-treated mice showed a lower diarrhea score, reduced inflammatory response in the colon, and reduced intestinal mucosal damage, which may be related to the increased level of butyric acid in fecal metabolites. In conclusion, this study provides evidence that taxifolin can ameliorate DSS-induced colitis by altering gut microbiota to increase the production of SCFAs.

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Ruminiclostridium 5, Parabacteroides distasonis, and bile acid profile are modulated by prebiotic diet and associate with facilitated sleep/clock realignment after chronic disruption of rhythms

Cited by 50 publications

References 105 publications

A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats

A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats

Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice

Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid

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