The fast growth of the Internet of Things (IoT) and its diverse applications increase the risk of cyberattacks, one type of which is malware attacks. Due to the IoT devices’ different capabilities and the dynamic and ever-evolving environment, applying complex security measures is challenging, and applying only basic security standards is risky. Artificial Immune Systems (AIS) are intrusion-detecting algorithms inspired by the human body’s adaptive immune system techniques. Most of these algorithms imitate the human’s body B-cell and T-cell defensive mechanisms. They are lightweight, adaptive, and able to detect malware attacks without prior knowledge. In this work, we review the recent advances in employing AIS for the improved detection of malware in IoT networks. We present a critical analysis that highlights the limitations of the state-of-the-art in AIS research and offer insights into promising new research directions.