Running exercise enhances motor functional recovery with inhibition of dendritic regression in the motor cortex after collagenase-induced intracerebral hemorrhage in rats

Takamatsu, Yasuyuki; Tamakoshi, Keigo; Waseda, Yuya; Ishida, Kenji

doi:10.1016/j.bbr.2015.12.003

Cited by 28 publications

(16 citation statements)

References 37 publications

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“…The motor deficit score was evaluated by observation of spontaneous ipsilateral circling, contralateral hindlimb retraction, beam walking ability and bilateral forepaw grasp, as previously described. 25 The specific tests as following: (1) observation of spontaneous ipsilateral circling, graded from 0 (no circling) to 3 (continuous circling); (2) contralateral hindlimb retraction, which measured the ability of the animal to replace the hindlimb after it was displaced laterally by 2 cm to 3 cm, graded from 0 (immediate replacement) to 3 (replacement after minutes or no replacement); (3) beam walking ability, which was graded 0 for a rat that readily traversed a 2.4 cm wide, 80 cm long beam to 3 for a rat unable to stay on the beam for 10 s; and (4) bilateral forepaw grasp, which measured the ability of the rat to hold onto a 2-mm diameter steel rod, graded 0 for a rat with normal forepaw grasping behavior to 3 for a rat unable to grasp with the forepaws.…”

Section: Methodsmentioning

confidence: 99%

“…The Beam Walking test evaluated the ability of the rats to walk along a wooden beam, and scores were assigned using methods previously described. 25 Performance was rated on a 7 point scale: (1) the rat is unable to place the affected hindlimb on the horizontal surface of the beam; (2) the rat places the limb on the beam and maintains balance but is unable to traverse the beam; (3) the rat traverses the beam dragging the affected hindlimb; (4) the rate traverses the beam and places the affected hindlimb on the horizontal surface of the beam once; (5) the rat crosses the beam and places the affected hindlimb on the horizontal surface of the beam to aid during less than half of the steps; (6) the rat uses the affected hindlimb to aid in more than half of the steps; and (7) the rat traverses the beam with no more than two foot slips.…”

Section: And 28 D After Exos Administrationmentioning

confidence: 99%

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<p>Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization</p>

Duan

Wang

Cao

et al. 2020

DDDT

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Introduction: Intracerebral hemorrhage (ICH) is a devastating type of stroke with high mortality, and the effective therapies for ICH remain to be explored. Exosomes (Exos) have been found to play important roles in cell communication by transferring molecules, including microRNAs (miRNAs/ miRs). MiRNAs are critical regulators of genes involved in many various biological processes and have been demonstrated to aggravate or alleviate brain damages induced by ICH. The aim of the present study was to investigate the effect of Exos derived from miR-146a-5p-enriched bone marrow mesenchymal stem cells (BMSCs-miR-146a-5p-Exos) on experimental ICH. Methods: ICH was induced in adult male Sprague-Dawley rats by an intrastriatal injection of collagenase type IV. At 24 h after surgery, Exos were administrated. For detecting apoptotic cells, TUNEL staining was performed using an in situ Cell Death Detection Kit. Fluoro-Jade B staining was performed to detect degenerating neurons. Immunofluorescence assay was performed to detect the expression of myeloperoxidase (MPO) and OX-42. The binding of miR-146a-5p and its target genes was confirmed by luciferase reporter assay. Results: At 24 h after surgery, BMSCs-miR-146a-5p-Exos administration significantly improved neurological function, reduced apoptotic and degenerative neurons, and inhibited inflammatory response. Furthermore, miR-146a-5p-enriched Exos obviously inhibited the M1 polarization of microglia after ICH in rats, accompanied by the reduced expression of pro-inflammatory mediators releasing by M1 microglia including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein-1 (MCP-1). Finally, we observed that miR-146a-5p directly targeted interleukin-1 receptor-associated kinase1 (IRAK1) and nuclear factor of activated T cells 5 (NFAT5), which contributed to the inflammation response and the polarization of M1 microglia/macrophages. Conclusion: We demonstrated that miR-146a-5p-riched BMSCs-Exos could offer neuroprotection and functional improvements after ICH through reducing neuronal apoptosis, and inflammation associated with the inhibition of microglial M1 polarization by downregulating the expression of IRAK1 and NFAT5.

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Section: Methodsmentioning

confidence: 99%

Section: And 28 D After Exos Administrationmentioning

confidence: 99%

<p>Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization</p>

Duan

Wang

Cao

et al. 2020

DDDT

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“…Numerous studies highlighted that forced treadmill training is more effective than all the other types of exercise, included voluntary exercise, to improve running function, aerobic fitness and to reduce infarct volume (Takamatsu et al, 2010 , 2016 ; Schmidt et al, 2014 ). However, some authors indicated that voluntary exercise is more effective to improve motor recovery using the De Ryck’s behavioral test (Ke et al, 2011 ).…”

Section: Motor Vs Cognitive Function Recovery: Can Aerobic Training mentioning

confidence: 99%

Influence of Aerobic Training and Combinations of Interventions on Cognition and Neuroplasticity after Stroke

Constans

Pin-Barre

Temprado

et al. 2016

Front. Aging Neurosci.

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Stroke often aggravated age-related cognitive impairments that strongly affect several aspects of quality of life. However, few studies are, to date, focused on rehabilitation strategies that could improve cognition. Among possible interventions, aerobic training is well known to enhance cardiovascular and motor functions but may also induce beneficial effects on cognitive functions. To assess the effectiveness of aerobic training on cognition, it seems necessary to know whether training promotes the neuroplasticity in brain areas involved in cognitive functions. In the present review, we first explore in both human and animal how aerobic training could improve cognition after stroke by highlighting the neuroplasticity mechanisms. Then, we address the potential effect of combinations between aerobic training with other interventions, including resistance exercises and pharmacological treatments. In addition, we postulate that classic recommendations for aerobic training need to be reconsidered to target both cognition and motor recovery because the current guidelines are only focused on cardiovascular and motor recovery. Finally, methodological limitations of training programs and cognitive function assessment are also developed in this review to clarify their effectiveness in stroke patients.

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“…Fifteen studies evaluated the effect of aerobic exercise training (Treadmill/ Bicycle ergometer/Motorized running wheel) on BDNF concentrations (14–16,, 19, 21–31, 35). Only one study evaluated systemic BDNF concentration following aerobic exercise training in humans post-stroke (19), while all others evaluated central BDNF concentration in animal models of stroke.…”

Section: Resultsmentioning

confidence: 99%

Post-stroke BDNF Concentration Changes Following Physical Exercise: A Systematic Review

et al. 2018

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Background: Research over the last two decades has highlighted the critical role of Brain-derived neurotrophic factor (BDNF) in brain neuroplasticity. Studies suggest that physical exercise may have a positive impact on the release of BDNF and therefore, brain plasticity. These results in animal and human studies have potential implications for the recovery from damage to the brain and for interventions that aim to facilitate neuroplasticity and, therefore, the rehabilitation process.Purpose: The aim of this study was to carry out a systematic review of the literature investigating how aerobic exercises and functional task training influence BDNF concentrations post-stroke in humans and animal models.Data Sources: Searches were conducted in PubMed (via National Library of Medicine), SCOPUS (Elsevier), CINAHL with Full Text (EBSCO), MEDLINE 1946—present with daily updates (Ovid) and Cochrane.Study Selection: All of the database searches were limited to the period from January, 2004 to May, 2017.Data Extraction: Two reviewers extracted study details and data. The methodological quality of the studies that used animal models was assessed using the ARRIVE Guidelines, and the study that evaluated human BDNF was assessed using the PEDro Scale.Data Synthesis: Twenty-one articles were included in this review. BDNF measurements were performed systemically (serum/plasma) or locally (central nervous system). Only one study evaluated human BDNF concentrations following physical exercise, while 20 studies were experimental studies using a stroke model in animals. A wide variation was observed in the training protocol between studies, although treadmill walking was the most common type of intervention among the studies. Studies were of variable quality: the studies that used animal models scored from 8/20 to 15/20 according to the ARRIVE Guidelines. The only study that evaluated human subjects scored 5/10 according to the PEDro scale and, which indicates a quality classified as “fair”.Conclusions: The results of the current systematic review suggest that aerobic exercise promotes changes in central BDNF concentrations post-stroke. On the other hand, BDNF responses following functional exercises, such as reaching training and Constraint Induced Movement Therapy (CIMT), seem to be still controversial. Given the lack of studies evaluating post-stroke BDNF concentration following physical exercise in humans, these conclusions are based on animal work.

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Running exercise enhances motor functional recovery with inhibition of dendritic regression in the motor cortex after collagenase-induced intracerebral hemorrhage in rats

Cited by 28 publications

References 37 publications

<p>Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization</p>

<p>Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization</p>

Influence of Aerobic Training and Combinations of Interventions on Cognition and Neuroplasticity after Stroke

Post-stroke BDNF Concentration Changes Following Physical Exercise: A Systematic Review

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